Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


Date of Approval Title
23/07/2020 Exploring patterns of healthcare resource utilisation and COPD exacerbations in patients with chronic obstructive pulmonary disease for health technology assessment
22/07/2020 Which patients with visual impairment need to access Falls Services? – Using big data to bridge the intervention gap
20/07/2020 Prevalence of haematuria and its association with risk of urinary tract cancer: a case-control study using real-world data from UK primary care
20/07/2020 Determining the applicability and feasibility of using regression discontinuity in electronic health record data
16/07/2020 The SPOtting Cancer among Comorbidities (SPOCC) programme. Work Package 1: Investigating comorbidities’ impact on intermediate cancer outcomes associated with the diagnostic process; a retrospective cohort study
16/07/2020 The effectiveness of aspirin in preventing COPD exacerbations: A prevalent new-user cohort study
16/07/2020 Bleeding events and adverse reactions in UK patients with venous thromboembolism (VTE) treated with edoxaban
16/07/2020 Strengthening the Evidence-Base for Drug-Disease Interactions in Older Adults
14/07/2020 A descriptive analysis of Pompe disease and Fabry disease based on UK electronic primary healthcare records and linked secondary care data
13/07/2020 Hormone replacement therapy and dementia risk: nested case-control studies using CPRD and QResearch
13/07/2020 Antibiotic prescribing and risk of herpes zoster: a case-control study
10/07/2020 Glycaemic control and diabetes-related health outcomes: longitudinal HbA1c trajectories, cumulative morbidity, and disease transitions in people with type 2 diabetes
09/07/2020 Asthma epidemiology, prevalence of asthma modifiable factors and healthcare utilisation due to asthma in England, Scotland, Wales, Northern Ireland and the UK
08/07/2020 The Incidence of Cancer Overall and Site-Specific Cancer Among Patients with Type 2 Diabetes Between 1988 and 2019
08/07/2020 Retrospective cohort study on first-time use of insulin detemir for diabetes type 2 glycaemic control in elderly and multimorbidity patients living in the United Kingdom
08/07/2020 Descriptive analysis of patterns of primary care demand in England during the COVID-19 pandemic
07/07/2020 Primary care service use towards end of life among patients who died before and during the COVID-19 epidemic: a nationwide cohort study using the Clinical Practice Research DataLink
06/07/2020 Understanding non-recovery after an exacerbation of chronic pulmonary obstructive disease
01/07/2020 Evaluation of the drivers in heterogeneity in unplanned hospital admissions and mortality in frail and multimorbidity elderly patients before and during/after COVID-19
29/06/2020 Selective Serotonin Reuptake Inhibitors and the Risk of Type 2 Diabetes Mellitus in Children and Youths