Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Protocols below are listed in order of date of approval. Please click on the study title for more details.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


Date of ISAC Approval Title
20/04/2020 Investigating early diagnoses of patients with ankylosing spondylitis using machine learning: a predictive modelling study
20/04/2020 Psychological distress associated with the current COVID-19 outbreak: evidence from electronic health records
20/04/2020 COVID-19 related risks in cancer survivors: a matched cohort study using linked UK electronic health records data
16/04/2020 COVID-19 and drugs acting on the renin angiotensin system
15/04/2020 Descriptive analysis of primary care consultations in England from 2000 to 2018
09/04/2020 Pharmacological risk factors for COVID-19 infection: a matched prospective cohort study of patients in primary care
31/03/2020 The use of primary care services among individuals with dementia approaching the end-of-life, and its association with multiple hospital admissions: a retrospective cohort study
27/03/2020 A primary care-based cohort study evaluating the utility of indefinite regular monitoring blood tests in detecting asymptomatic toxicity from long-term methotrexate and leflunomide prescription
27/03/2020 Cardiovascular disease in type 2 diabetes: characterisation of treatment variation in the UK CPRD
25/03/2020 Identifying risk factors for infection with the new coronavirus (COVID-19)
23/03/2020 Characterisation, prediction of complications, and safety of emergent therapies for viral outbreaks and pneumonia: a rapid network study to inform management of COVID-19
13/03/2020 Analysing the effect of lithium cessation on renal function in patients with bipolar disorder
11/03/2020 Risk of death in childhood epilepsy
04/03/2020 Measuring the incidence and prevalence of menstrual disorders in the UK Clinical Practice Research Datalink
04/03/2020 Risk factors for pertussis in older adults aged 50 years and above, and the incidence and economic burden of pertussis overall and in high-risk groups using the merged CPRD GOLD and Aurum database, and Hospital Episode Statistics (HES)
28/02/2020 SELECT: Selection of Eligible People for Lung Cancer Screening using Electronic Primary Care DaTa: Validation of pre-existing prediction models
28/02/2020 Utilisation, effectiveness, and safety of direct oral anticoagulants in patients with non-valvular atrial fibrillation and liver disease
27/02/2020 Screening for diabetes and glucose intolerance disorders after gestational diabetes in primary care: A retrospective cohort analysis from the UK Clinical Practice Research Datalink (CPRD)
27/02/2020 Association of diabetes control on the risk of venous thrombosis: a nested case control study
18/02/2020 A retrospective cohort study to assess whether urate lowering therapy improves outcomes in patients with hyperuricemia and/or gout with a history of heart failure