Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Protocols below are listed in order of date of approval. Please click on the study title for more details.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
08/12/2015 Congenital malformations and maternal use of anti-hypertensive medication in the UK
03/12/2015 Clinical & Economic Burden of Diabetic Foot Ulcer Care Pathways in the UK
02/12/2015 Descriptive study of patients in the CPRD with lysosomal function disorders.
02/12/2015 Use of Finasteride 1mg for Alopecia and the Incidence of Erectile Dysfunction (ED)
30/11/2015 Association between Use of Beta-blockers or Diuretics and Incident Meniere's Disease
30/11/2015 A descriptive study of LAIV utilization to identify and characterize medication errors due to expired vaccine use in individuals 2-17 years of age in the CPRD
27/11/2015 Prescribing Trends of ADHD Medications in UK Primary Care
26/11/2015 Comparison of the performance of the English NHS Health Checks & Scottish Keep Well programmes
19/11/2015 Effects of selective serotonin reuptake inhibitors on the risk of mortality in patients with epilepsy: a CALIBER study using linked data
19/11/2015 Using pharmacoepidemiology to test medications associated with altered breast cancer risk identified from connectivity mapping
17/11/2015 The role of systemic inflammatory diseases in long-term morbidity and mortality: a retrospective, matched-cohort study in the Clinical Practice Research Datalink
16/11/2015 Is gout a risk factor for erectile dysfunction?
04/11/2015 Stress Urinary Incontinence and Suicidality Seen in the Clinical Practice Research Datalink (CPRD)
04/11/2015 Descriptive Characteristics of the Clinical Practice Research Datalink (CPRD) EMIS database.
27/10/2015 Determinants of Zoster vaccination acceptance in people eligible for NHS shingles vaccination programme
27/10/2015 Morbidity among HIV-positive people in England: a cross-sectional, population-based CALIBER study
27/10/2015 Prediagnostic presentations and comorbidities of multiple sclerosis in primary care: a case-control study
19/10/2015 Usage Patterns of Selected Systemic NSAIDs (Including Diclofenac): A Retrospective Cohort Study
14/10/2015 The association between lansoprazole and tuberculosis disease; a primary care based cohort study
14/10/2015 A study of multifactorial intervention in type 2 diabetes and chronic kidney disease