Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


Date of Approval Title
22/02/2019 Understanding the harms of antihypertensives, statins and antiplatelets for prevention of cardiovascular disease: A prognostic modelling and casual inference study
21/02/2019 Characteristics of patients initiating Spiriva Respimat in Asthma in the UK: a cross-sectional study based on the Clinical Practice Research Datalink
21/02/2019 Characterisation and natural history of non-exacerbating chronic obstructive pulmonary disease patients in a general practice-based population
21/02/2019 The impact of musculoskeletal conditions on outcome of hospital care for acute coronary syndrome and stroke: a linked electronic health record study
21/02/2019 All-cause Mortality in Infants vaccinated in the routine childhood immunisation schedule in general practice in the United Kingdom
14/02/2019 Comparative safety profile of antidiabetic drug regimens containing SGLT-2 inhibitors and/or GLP-1 receptor agonists among type 2 diabetes patients
12/02/2019 What are the optimal blood pressure targets for patients in atrial fibrillation treated with non-vitamin K antagonist oral anticoagulants?
12/02/2019 Use of Sodium-glucose co-transporter-2 inhibitors, changes in body mass index and risk of major osteoporotic fracture
11/02/2019 Evaluation of clinical progression of chronic kidney disease and its predictors using statistical and machine learning techniques: a retrospective cohort study from United Kingdom
11/02/2019 Utilization, Effectiveness, and Safety of SGLT2 Inhibitors Among Patients with Type 2 Diabetes Mellitus
11/02/2019 The weight loss effects of glucagon-like peptide-1 receptor agonists and the risk of breast cancer in women with type 2 diabetes
08/02/2019 Investigating the extent to which exposure to varicella boosts Varicella zoster virus-immunity: a self-controlled case-series, 1997-2018
08/02/2019 Trends in incidence of first diabetic foot ulcer and mortality in patients with type I and type II diabetes mellitus
08/02/2019 Treatment pathways to severe asthma and health care resource utilisation in the UK
08/02/2019 Risks of antidepressants on cardiovascular mortality and morbidity, suicidality, falls and fractures in people with obesity and depression in primary care
07/02/2019 Validation of Asthma-COPD Overlap Syndrome in the Clinical Practice Research Datalink (CPRD)
05/02/2019 Type 2 Diabetes in women after a diagnosis of gestational diabetes: understanding uptake to screening and progression rates- a retrospective cohort study in the CPRD database
05/02/2019 The association of cancer and autism spectrum condition in a UK population
04/02/2019 Estimating the prevalence of transthyretin amyloid cardiomyopathy in the UK
01/02/2019 Characterising end of life health care expenditure