Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


Date of Approval Title
23/12/2015 Incidence and Prevalence of the Parkinson's Disease in the United Kingdom during 1987-2014
23/12/2015 Novel Prediction Models for the One-Year Competing Risks of Death, Stroke, Intracranial Hemorrhage, and Extracranial Hemorrhage in Adults with Incident Non-Valvular Atrial Fibrillation
29/12/2015 Prescribing of antidepressants and adverse outcomes in patients with chronic kidney disease
30/12/2015 Quality and completeness of recording of social factors related to vaccine uptake in linked electronic health records
31/12/2015 Association between Diabetes Mellitus and Incident Meniere's Disease
31/12/2015 Validation of the recording of asthma diagnosis in adult patients in the Clinical Practice Research Datalink
04/01/2016 Domperidone and risk of primary liver cancer in the UK Clinical Practice Research Datalink
12/01/2016 The risk of Clostridium Difficile Colitis and of pneumonia in persons with pernicious anaemia.
12/01/2016 Maternal Depression and Antidepressant Use During Pregnancy and Risk of Childhood Autism Spectrum Disorders (ASD) in Offspring: Population-based Cohort and Bidirectional Case-Crossover Sibling Study
14/01/2016 Burden of Multiple Myeloma (MM) in England: regional equity based on Real world data from CPRD HES, and Cancer Registry linked data.
14/01/2016 Risk factors for influenza-related complications in children
22/01/2016 Assessing the Management and Clinical Outcomes of Patients with Non-Diabetic Intermediate Hyperglycaemia in UK Primary Care
22/01/2016 Treatment of first-time traumatic anterior shoulder dislocation (UK.TASH-D Study)
28/01/2016 Temporal Trend of Severe Hypoglycaemia and Diabetic Ketoacidosis and the Relationship Between HbA1c or HbA1c variability and Risk of Severe Hypoglycaemia and Diabetic Ketoacidosis
28/01/2016 Statin use and incident Achilles or biceps tendon rupture
02/02/2016 Bleeding Events and oral Anticoagulant Treatment in non-valvular atrial fibrillation (Heart-BEAT study): a cohort study based on CPRD-HES data
09/02/2016 Does better quality of primary care influence admissions and health outcomes for people with serious mental illness (SMI)? A linked patient-level analysis of the full patient care pathway
10/02/2016 Depression, prescription of antidepressant drugs and changes in body weight: A cohort study using electronic health records
10/02/2016 Demography and pattern of causes of death in recognised alcohol misusers in the English General Practice (GP) population
10/02/2016 Drospirenone-containing combined oral contraceptives and risk of venous thromboembolism