Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Protocols below are listed in order of date of approval. Please click on the study title for more details.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


Date of ISAC Approval Title
17/12/2019 Improved characterization of the overlap syndrome of heart failure, diabetes mellitus and chronic kidney disease
17/12/2019 External validation study investigating the association between hormonal contraceptives and asthma onset in females of reproductive age
13/12/2019 Assessment of production batch information of vaccines in the Clinical Practice Research Datalink
06/12/2019 The prevalence of liver enzyme and function testing in UK primary care
28/11/2019 Infectious burden and the risk of incident dementia: a nested case-control study
27/11/2019 Identifying and describing the burden of morbidity following major surgery: a linked electronic health records cohort study
27/11/2019 The economic and clinical burden of hyperkalaemia in England: a retrospective cohort study using the Clinical Practice Research Datalink
27/11/2019 Spillover effects of removing indicators from the Quality and Outcomes Framework
21/11/2019 Safety of colchicine prophylaxis when initiating urate-lowering therapy for gout and prognostic factors for adverse events: an observational study in UK primary care using the Clinical Practice Research Datalink
20/11/2019 Examining variations in prescribing safety for patients with mental illness in UK primary care
20/11/2019 Co-prescribing of aldosterone antagonist and renin-angiotensin system drugs for heart failure in the UK primary care: assessing the impact of regulatory action
20/11/2019 Comparative effectiveness of the cardiorenal disease outcomes between SGLT-2i and DPP-4i medication in population with type 2 diabetes - an observational study across England
15/11/2019 Utilization and comparative effectiveness and safety of long-acting insulins and Neutral Protamine Hagedorn (NPH) in patients with type 2 diabetes
11/11/2019 Incidence of adverse events among adult users of insulin and apomorphine pumps in the United Kingdom Clinical Practice Research Datalink GOLD: a descriptive study
08/11/2019 Eosinophilic asthma phenotypes and associated clinical outcomes
08/11/2019 The association between anticoagulants and cancer incidence among individuals with atrial fibrillation.
06/11/2019 DISCOVER CKD: An observational study incorporating UK CPRD data to evaluate and describe the journey and management of patients with chronic kidney disease (CKD).
01/11/2019 Which histological subtypes of lung cancer exhibit underlying pre-diagnostic thrombocytosis?
01/11/2019 Patient and clinical characteristics of new users to single or multiple inhaled triple therapy in patients with COPD in the UK
01/11/2019 Comparative effectiveness and safety of NOACs versus warfarin in UK patients with non-valvular atrial fibrillation and type 2 diabetes: a retrospective cohort study