Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Protocols below are listed in order of date of approval. Please click on the study title for more details.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


Date of ISAC Approval Title
30/10/2019 Association of chronic kidney disease with frailty and mortality in the multi-ethnic UK population: a CPRD study
25/10/2019 Health care demand modelling - Time series analysis of the incidence and prevalence of multiple chronic conditions and comorbidities in England from primary care data
24/10/2019 Burden of hip dislocation following total hip arthroplasty in England.
16/10/2019 Use of sodium-glucose co-transporter-2 inhibitors (SGLT-2-Is) and risk of lower limb amputation.
11/10/2019 The effect of low-dose oral glucocorticoid therapy on osteoporotic fracture risk in patients with rheumatoid arthritis: the UK Clinical Practice Research Datalink GOLD
11/10/2019 Effect of raised cardiovascular risk on the rates of acute respiratory infections and subsequent cardiovascular complications: a cohort study using electronic health records
09/10/2019 Cardiovascular prognosis in patients with undiagnosed chest pain: an electronic health record cohort study
09/10/2019 Characterization of the deterioration of type 2 diabetes in patients with a subsequent diagnosis of pancreatic cancer - A descriptive study
09/10/2019 Cohort study examining mortality and physical morbidity outcomes among patients diagnosed with an eating disorder
08/10/2019 Post Authorisation Safety Study (PASS) to Evaluate the Risks of Hepatotoxicity and Nephrotoxicity from Administration of Methoxyflurane (Penthrox) for Pain Relief in Hospital Accident & Emergency Departments in the United Kingdom
08/10/2019 The Plan-it study: The acceptability and feasibility of a planned pre-pregnancy weight loss intervention
07/10/2019 Impact of variability in patient characteristics on effect estimates in observational studies: a retrospective multi-cohort study of rivaroxaban versus warfarin
03/10/2019 Polypharmacy and the impact of drug interactions with direct oral anticoagulants (DOACs)
27/09/2019 Patient pathway and therapeutic inertia in newly diagnosed T2DM patients with multimorbidity
26/09/2019 The Prevalence of Clostridioides difficile Infections (CDIs) in Age- and Comorbidity-Based Risk Groups in England: The PERFECT Study
26/09/2019 Treatment, Complications, and Costs in Clavicle Fracture and Acromioclavicular Dislocation
19/09/2019 Effectiveness of BISOprolol on high blood PRESSure versus other Beta -blockers, and versus other anti-hypertensive classes. A cohort study in the UK Clinical Practice Research Datalink (CPRD)
19/09/2019 Burden of pneumococcal disease and pneumococcal vaccination in adults with underlying medical conditions in the UK
19/09/2019 Ageing Inequalities: A cohort study to investigate delay in diagnosis and inequalities in treatment of dementia and cancer in the elderly
11/09/2019 Hypertensive disorders of pregnancy and risk of cardiovascular disease in women: electronic cohort study in primary care