Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Protocols below are listed in order of date of approval. Please click on the study title for more details.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


Date of ISAC Approval Title
06/09/2019 Utilization of routinely performed diagnostic tests in primary care
05/09/2019 Evaluation of the survival, treatment pathways and liver disease outcomes of patients with liver disease and their progression to cirrhosis and hepatic encephalopathy: a non-interventional study using primary and secondary healthcare data from the UK
30/08/2019 GLP-1 receptor agonists and the risk of anaphylactic reactions among patients with type 2 diabetes
28/08/2019 A real-world study comparing the effectiveness and safety of glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose co-transporter 2 inhibitors (SGLT-2is) in patients with type 2 diabetes
22/08/2019 Equity dynamics of multimorbidity in England over time: a descriptive study on trends of incident and prevalent multimorbidity by age, sex, and socioeconomic status
22/08/2019 Comparative Long-Term Effectiveness of Treatments for Patients with Drug-Resistant Epilepsy: a descriptive study
20/08/2019 Estimating primary and secondary healthcare resource costs for people with type 1 and type 2 diabetes in the United Kingdom
20/08/2019 A multi-database retrospective study of the comparative efficacy and safety of SGLT2 inhibitors in the management of type 2 diabetes (EMPRISE-UK)
12/08/2019 Statins and the risk of Venous Thromboembolism
07/08/2019 The long-term impact of vaginal surgical mesh devices in UK primary care: a cohort study in the CPRD
05/08/2019 Occurrence and consequences of Langerhans cell histiocytosis, Malignant Histiocytosis, Erdheim-Chester Disease and Haemophagocytic Lymphohistiocytosis: a population based cohort study
05/08/2019 Association of Polycystic Ovary Syndrome with patient and offspring cardiometabolic outcomes: a retrospective, observational study
31/07/2019 Use of the STarT Back Screening Tool for Low Back Pain in Primary Care
31/07/2019 A non-interventional retrospective study in England and Scotland estimating the economic burden of moderate-to-severe chronic pain due to osteoarthritis (OA) or chronic low back pain (CLBP)
26/07/2019 Trends in Prescription of Antihypertensive Medications in UK Primary Care Practices, 1988-2018
26/07/2019 Suspected cancer symptoms and blood test results in primary care before a diagnosis of lung cancer: a case-control study
26/07/2019 5-Alpha Reductase Inhibitors and the Risk of Anaemia
26/07/2019 The balance between face-to-face and phone consultations in primary care and its effect on hospital demand: A longitudinal observational study
24/07/2019 Uncontrolled blood pressure and therapeutic inertia in treated hypertensive patients: a retrospective descriptive cohort study using CPRD
24/07/2019 Comparative effectiveness of gliclazide MR and sitagliptin as second line treatment after metformin monotherapy in uncontrolled type 2 diabetes patients using the UK Clinical Practice Research Datalink (CPRD) database