Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Protocols below are listed in order of date of approval. Please click on the study title for more details.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
02/04/2019 Hydroxychloroquine and screening for risk of ocular toxicity - how big is the problem? Epidemiology of hydroxychloroquine prescriptions in the UK Clinical Practice Research Datalink
02/04/2019 An investigation into the association of asthma and fractures
02/04/2019 Influence of allopurinol use on hepatotoxicity risk with thiopurine use among adults and paediatrics: a retrospective population-based cohort study
01/04/2019 Cardiovascular risk prediction in daily practice: can machine-learning based risk prediction models improve the accuracy of risk prediction for individual patients?
29/03/2019 The risk of muscular events in new users of individual hydrophilic versus lipophilic statins at equivalent doses: An observational cohort study
29/03/2019 Risk of non-melanoma skin cancer among hypertensive adults in the United Kingdom treated with angiotensin converting enzyme inhibitors: a population based, active comparator, new user, retrospective cohort study
26/03/2019 All Cause and Cardiovascular Mortality in type 2 diabetes patients using Detemir or Glargine
26/03/2019 Assessment of off-label use of baricitinib in the paediatric population in the United Kingdom
22/03/2019 Sodium channel-inhibiting drugs and cancer survival: a cohort study
19/03/2019 Validation of CPRD database transformed to Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM)
18/03/2019 Data analysis of the current treatments for major depressive disorder and treatment resistant depression in the United Kingdom
18/03/2019 Developing and validating a novel clinical severity index for cardiovascular disease in primary care
13/03/2019 Epidemiology of Endometriosis in the Adolescent Population
13/03/2019 Delayed treatment intensification and risk of micro- and macrovascular complications in insulin-treated patients with type 2 diabetes; a United Kingdom Clinical Practice Research Datalink Retrospective Cohort Study
13/03/2019 Bereavement amongst those with chronic kidney disease - does it affect outcomes?
12/03/2019 Database - Prescription Event Monitoring (D-PEM) study to identify, quantify and characterise identified adverse events associated with the use of a widely prescribed medication in primary care in the UK
12/03/2019 Determining the optimal timing of triple therapy initiation in patients with chronic obstructive pulmonary disease (COPD) in the United Kingdom (UK): A retrospective, longitudinal cohort study
11/03/2019 Weight change following type 2 diabetes diagnosis and incidence of cardiovascular events and all-cause mortality
11/03/2019 A matched population-based case control study to determine which clinical features are associated with the inherited cardiac conditions, bicuspid aortic valve and long QT syndrome in primary care
11/03/2019 Epidemiology of osteoarthritis and associated comorbidities: a combined case-control and cohort study