Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


Date of Approval Title
21/04/2016 The association between severe mental illness and chronic kidney disease: a cross sectional study
21/04/2016 Prescribing patterns of dependence forming medicines: Benzodiazepines, z-drugs, opioids and GABAergic drugs
21/04/2016 A prevalence and incidence study of multimorbidity in the UK using the Clinical Practice Research Datalink (CPRD)
21/04/2016 A Retrospective Descriptive Study of the Cohort of Type 2 Diabetes Mellitus Patients Initiating a Second-line Therapy in the United Kingdom Clinical Practice Research Datalink (CPRD) Database
21/04/2016 Urinary tract infections in the elderly - care pathways and characteristics
21/04/2016 Assessing drivers of effectiveness and safety using real life data: anticoagulants as a case study
29/04/2016 Premature mortality and non-fatal self-harm in patients diagnosed with Chronic Fatigue Syndrome
03/05/2016 Descriptive Epidemiology of Multimorbidity in Primary Care: A Cross-Sectional Study
03/05/2016 Treatment choice and outcomes associated with dry powder inhaler and Tiotropium Respimat monotherapy in COPD (chronic obstructive pulmonary disease) patients
05/05/2016 Androgen Deprivation Therapy for Prostate Cancer and the Risk of Anaemia
05/05/2016 Examining the impact of national guidelines on antipsychotic drug prescribing to older people with dementia
05/05/2016 Examining changing patterns of antidepressant use in children, 2000 to 2015
09/05/2016 Are primary care factors associated with hospital admissions for adverse drug reactions among the population with type 2 diabetes? A national observational study
10/05/2016 An observational evaluation of prescribing of fixed-dose combination inhaled corticosteroid / long-acting beta2-agonist (ICS/LABA): fluticasone propionate / formoterol (FP/FOR) and adverse events in routine primary care at 36-months post launch
10/05/2016 Development of small population prevalence models for COPD and asthma
11/05/2016 Mortality recording in the Clinical Practice Research Datalink
11/05/2016 Health Care Utilisation, Care Pathways and Educational Status in Children and Young People with Adolescent Mental Health Disorders
12/05/2016 Does the use of inhaled corticosteroids increase the incidence and disease burden of Type 2 Diabetes, osteoporosis or pneumonia compared to non-ICS therapies in patients with Chronic Obstructive Pulmonary Disease.
17/05/2016 Estimation of multi-treatment effects from observational data with application to diabetes mellitus
17/05/2016 A longitudinal safety study of patients with psoriasis and psoriatic arthritis treated with either Otezla (apremilast) or a comparator drug