Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


Date of Approval Title
15/12/2020 Use and effectiveness of physical activity and dietary based lifestyle interventions for patients with hypertension
15/12/2020 "A cohort study of mortality in the Clinical Practice Research Datalink (CPRD) primary care database - CPRD Aurum"
15/12/2020 A cohort study of the care home population in CPRD Aurum
15/12/2020 Investigating drug-disease relationship through directed graph mapping: interactions, indications and contraindications
15/12/2020 Investigating the effect of cardiovascular risk level on severe outcomes of COVID-19
11/12/2020 The benefits and side effects of osteoporosis medications: A regression discontinuity study of primary care patients in the UK.
09/12/2020 Distributional and heterogeneous treatment effects of health care interventions for gestational diabetes using regression discontinuity in electronic health record data
08/12/2020 Emotional and behavioural dysregulation markers in late childhood and early adolescence as risk factors for mental illness and healthcare utilisation in young people at the age of 18-24
08/12/2020 European non-interventional post-authorization safety study related to serious cardiovascular events of myocardial infarction and stroke and all-cause mortality for romosozumab by the EU-ADR Alliance
08/12/2020 Patterns of multimorbidity, multimorbidity clusters and associations with mortality in patients with intellectual disabilities in the UK.
08/12/2020 Venous Thromboembolism and Cancer Treatment, Outcomes and Resource Use in England
04/12/2020 Women's preconception health in General Practice: Understanding how women interact with GP services prior to becoming pregnant, and the impact of preconception health on pregnancy outcomes for women and babies
02/12/2020 The impact of painful musculoskeletal conditions on management and outcomes of cancer: a linked electronic health record study
02/12/2020 The SPECTRUM Study - Stratifying phenotypes in Chronic Obstructive Pulmonary Disease: An observational study of treatment allocations using the updated National Institute fie Health and Care Excellence recommendations in England
02/12/2020 Temporal trends in arthroscopic subacromial decompression during and after conduct of a large UK multi-centre trial
02/12/2020 Non-Interventional retrospective longitudinal study in the UK to evaluate and identify the best practices for switching of valproate and related substances in clinical practice
01/12/2020 The risk factors for hospital admission amongst people with parkinsonism in the UK.
01/12/2020 A Retrospective Observational Cohort Study Describing Epidemiology, Patient Characteristics, Treatment Patterns and The Potential Burden Of Inhaled Short Acting Beta-2 Agonist (SABA) Over-prescription And Inhaled Corticosteroids (ICS) Under-prescription A
01/12/2020 Producing epidemiologic estimates by cancer type in England: A cohort study using linked primary care to secondary data sources
01/12/2020 Assessment of the burden of chronic kidney disease (CKD) in patients with type 2 diabetes (T2D) in England