Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


Date of Approval Title
01/12/2020 Understanding the association between diabetes and severe COVID-19 infection.
01/12/2020 Effectiveness and cost-effectiveness of alcohol use screening tests and treatments for alcohol-use disorders
01/12/2020 Epidemiology, Natural History and Burden of Disease in Patients with Alpha-1 Antitrypsin Deficiency in the UK: A Real-World Retrospective Cohort Study
25/11/2020 Who benefits and who suffers harm from discontinuation of renin-angiotensin-aldosterone system inhibitors? A regression discontinuity study
24/11/2020 Determining the incidence, prevalence and impact of Psoriatic Arthritis and Fibromyalgia or Chronic Widespread Pain in UK Primary Care: A Health Intelligence Analysis.
24/11/2020 Feasibility analysis of a European infrastructure for COVID-19 vaccine monitoring: Background rates of Adverse Events of Special Interest
23/11/2020 Effectiveness of primary care COPD management in the UK: a regression discontinuity design
20/11/2020 Polycystic ovarian syndrome and metformin use in pregnant woman. Possible reduction of fetal loss. A cohort study in the Clinical Practice Research Datalink.
19/11/2020 Re-evaluating the clinical and cost effectiveness of implantable cardioverter defibrillator (ICD) or cardiac resynchronisation therapy with defibrillation (CRT-D) for heart failure using real world data from the Clinical Practice Research Datalink.
18/11/2020 Effects of oral anticoagulation in patients with atrial fibrillation and close-to-threshold stroke risk score (CHA2DS2-VASc) or chronic kidney disease: A regression discontinuity analysis
18/11/2020 Health Outcomes Arising from Human-Animal Interactions Including Zoonotic Disease and Antimicrobial Resistance
16/11/2020 The role of clinical and care factors in the delay of heart failure diagnosis and subsequent prognosis: a cohort study using the Clinical Practice Research Datalink (CPRD)
16/11/2020 Use and effectiveness of physical activity and dietary based lifestyle interventions for patients with hypercholesterolaemia
13/11/2020 An assessment of the cardiovascular health of autistic individuals
11/11/2020 A combined cross-sectional and cohort study to describe and quantify polypharmacy among people prescribed antidepressants, including quantifying frequent drug combinations and adverse events
11/11/2020 Estimating Incidence and Prevalence of Atherothrombotic Events in Coronary Artery Disease, Peripheral Artery Disease and Ischaemic Stoke Patients on Standard of Care Antiplatelet Treatment: a England Cohort Study
11/11/2020 Use and effectiveness of physical activity and dietary based lifestyle interventions for obesity
11/11/2020 European non-interventional post-authorisation safety study (PASS) related to serious infections associated to romosozumab by the EU-ADR Alliance
10/11/2020 Acute and long-term health outcomes for people who survived COVID-19: matched cohort analyses using UK primary and secondary care data
03/11/2020 Development of an algorithm to identify Hypereosinophilic Syndrome using the Clinical Practice Research Datalink linked with hospital data