Alcohol misuse and injury outcomes in adolescents aged 10-24 using linked UK health data

Date of Approval
Application Number
15_175
Technical Summary

Injuries are the leading cause of mortality among young people within the UK, leading to large numbers of hospital admissions every year. Existing studies assessing health outcomes of hazardous or harmful alcohol consumption are often limited by small sample sizes, being cross-sectional, and relying on self-reported alcohol intake and outcome information. There are few population-based studies of alcohol-related health outcomes among young people; none using linked primary and secondary care data in the UK. Using a cohort aged 10-24 with linked CPRD and inpatient HES data, for the period 1997-2014, we will assess whether young people with an alcohol-specific hospital admission have a higher risk of injury than controls. We will match up to 10 controls (without an alcohol-specific hospital admission between age 10-24) per case on age and general practice. We will estimate incidence rates, unadjusted and adjusted hazard rate ratios of injury and 95% confidence intervals using Cox regression to compare those with and without an alcohol-specific hospital admission. Age, sex, region, calendar year and socioeconomic status will be investigated as potential confounders. A greater understanding of injury consequences among young people who misuse alcohol will help develop more targeted and evidence based prevention and harm minimisation programmes.

Collaborators

Elizabeth Orton - Chief Investigator - University of Nottingham
Louise Lester - Corresponding Applicant - University of Nottingham
Ruth Baker - Collaborator - University of Nottingham

Linkages

HES Admitted Patient Care;Patient Level Index of Multiple Deprivation;Practice Level Index of Multiple Deprivation