Cataract in patients with diabetes mellitus

Date of Approval
Application Number
16_065
Technical Summary

The study aims to describe the incidence of cataract in patients with diabetes mellitus in the UK and compare it (stratified by age, sex and year of diagnosis) to a random sample of the general (non-diabetic) population. Furthermore, we will calculate incidence rates of cataract in subpopulations of patients with diabetic retinopathy or macular edema.
We will use COX proportional hazards modelling (adjusted for age, gender and index year of diabetes diagnosis) to assess time to cataract in newly diagnosed diabetic patients.
Additionally, we will carry out a nested case-control analysis in diabetic patients with or without cataract to identify risk factors for cataract development. We will perform conditional logistic regression analysis using SAS software.

Health Outcomes to be Measured

Incidence rates of cataract in patients with a diabetes diagnosis Hazard ratio of cataract associated with a diabetes diagnosis Odds ratio for cataract associated with diabetes duration, HbA1c, exposure to antidiabetic drugs

Collaborators

Christoph Meier - Chief Investigator - University of Basel
Claudia Becker - Corresponding Applicant - University of Basel
Annette Beiderbeck - Collaborator - Takeda Europe Ltd
Cornelia Schneider - Collaborator - University of Basel
David Neasham - Collaborator - Amgen Ltd
John Hall - Collaborator - IQVIA
Susan Jick - Collaborator - BCDSP - Boston Collaborative Drug Surveillance Program