Characterising the natural history and risk factors for the development of psoriatic arthritis in a UK population

Date of Approval
Application Number
15_154
Technical Summary

This study forms part of a wider NIHR funded Programme Grant (RP-PG-1212-20007) on the impact of early diagnosis of PsA. The proposed study aims to describe the incidence, prevalence and evolution of musculoskeletal symptoms reported to general practitioners by people with psoriasis in UK primary care and investigate predictors of the development of PsA in people with psoriasis, such as obesity and smoking. The study will follow a cohort study design and identify cases of psoriasis and PsA in the Clinical Practice Research Datalink, between 01/01/1998 and 31/12/2014, and follow them prospectively until the end of the study period or the time they leave the database. The incidence and prevalence of musculoskeletal symptoms will be calculated for each year after entry into the study period stratified by age, sex and psoriasis disease severity and survival rates from musculoskeletal symptom presentation to PsA diagnosis will be calculated. Generalised linear models with time varying covariates will be used to investigate factors associated with the development of PsA. Additionally, co-morbidity in PsA and the utilisation of primary health care resources before and after PsA diagnosis will be described to inform the cost-effectiveness component of the wider Programme Grant.

Collaborators

Rachel Charlton - Chief Investigator - University of Bath
Rachel Charlton - Corresponding Applicant - University of Bath
Alison Nightingale - Collaborator - University of Bath
Gavin Shaddick - Collaborator - University of Bath
Laura Bojke - Collaborator - University of York
Neil McHugh - Collaborator - University of Bath