Descriptive assessment of the Hospital Treatment Insights database and its link to the Clinical Practice Research Datalink for research on antibiotic dispensing in English hospitals

Date of Approval
Application Number
16_102
Technical Summary

Due to the way in which data for Hospital Treatment Insights is collected, an absence of a dispensing record is not equal to there not having been a drug administered and there is need to quantify the extent to which this affects recording for different drugs. Thus, the usefulness of the full Hospital Treatment Insights database and the subset linked to the Clinical Practice Research Datalink for research on antibiotic dispensing in hospitals in England will be explored using descriptive statistics. We will calculate prevalence rates and 95% confidence intervals for demographic variables, diagnoses for clinical infectious syndromes and antibiotic dispensing to provide insight into the representativeness of the separate populations included in the two datasets. Variations will be explored by stratifying by calendar year, age, sex and type of antibiotic. Similar statistics will be used to further explore dispensing for community-acquired pneumonia and under-recorded individual-level dispensing will be quantified where possible. If time and sample sizes allow for it, the results will be compared to the same estimates for urinary tract infection, cellulitis and sepsis.

Health Outcomes to be Measured

The primary outcome is the number of dispensed antibiotics of a list of clinically relevant antibiotics within the same Hospital Episode Statistics episode.

Collaborators

Joseph Kim - Chief Investigator - IQVIA - UK
Eleanor King - Collaborator - IQVIA ( IMS Health ) France
Elizabeth Williamson - Collaborator - London School of Hygiene & Tropical Medicine ( LSHTM )
Laura Shallcross - Collaborator - University College London ( UCL )
Matthew Hankins - Collaborator - IQVIA - UK
Patrick Rockenschaub - Collaborator - University College London ( UCL )
Rachel Tham - Collaborator - IQVIA Ltd

Linkages

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