Differences in morbidity and mortality in men and women with chronic obstructive pulmonary disease and peripheral arterial disease

Date of Approval
Application Number
21_000524
Technical Summary

The aim of this study is to describe the differences in morbidity and mortality in men and women with both chronic obstructive pulmonary disease (COPD) and peripheral arterial disease (PAD) as they commonly co-occur. The study will be undertaken utilizing linked data within the Clinical Practice Research Datalink GOLD and Aurum databases with Hospital Episode Statistics (HES) and Office for National Statistics (ONS) databases. We will describe baseline characteristics in the two groups (including demographics, health behaviours (e.g. smoking), co-morbidities, treatment for COPD, and COPD severity) and compare all-cause mortality and cause specific mortality (cardiovascular) between the two groups using Cox proportional hazard models. We will also compare management and complications in the two groups including drug treatments and revascularisation procedures, major cardiovascular events and acute limb ischaemia.

Health Outcomes to be Measured

The primary outcome is all-cause mortality
The secondary outcomes are 1)Cardiovascular specific mortality 2) acute limb ischaemia

Collaborators

Jennifer Quint - Chief Investigator - Imperial College London
Jennifer Quint - Corresponding Applicant - Imperial College London
Laura Portas - Collaborator - Imperial College London

Linkages

HES Admitted Patient Care;ONS Death Registration Data;Patient Level Index of Multiple Deprivation