Retrospective cohort study comparing the differential risk of ophthalmology hospital referrals/episodes and coincident lubricant prescriptions in two cohorts of patients. The two cohorts are patients prescribed a) preservative-free formulations (Monopost-cohort 1) or b) preservative-containing formulations (latanoprost-cohort 2).The primary outcomes will be a) the annual rate of hospital referrals to ophthalmology and b) ophthalmology related hospital episodes for patients with linked Hospital Episode Statistics (HES) data. The secondary outcome is the rate of coincident lubricant eye drop prescribing in the two cohorts. As the two cohorts will be matched on age, gender and practice any observed differences are likely to be due to the preservative.
Primary outcomes are hospital referrals from general practice to hospital ophthalmology and ophthalmology related hospital episodes as recorded in Hospital Episode Statistics. The secondary outcome is the rate of lubricant prescriptions in the study cohorts.
Martin Frisher - Chief Investigator - Keele University
Martin Frisher - Corresponding Applicant - Keele University
Nick Gibbons - Collaborator - Keele University
Stephen Chapman - Collaborator - Keele University