Epidemiology of venous thromboembolism in patients with active cancer: a population-based cohort study

Date of Approval
Application Number
16_031
Technical Summary

The proposed study aims to estimate the incidence rate of first venous thromboembolism (VTE) in patients with active cancer, and the subsequent risk of recurrent VTE and mortality.
The study will follow a cohort design. One study cohort of patients with active cancer-associated first VTE will be derived from the active-cancer subset of a previously identified cohort of patients with a first VTE. A second cohort with cancer but without VTE will be derived separately.
Descriptive analyses will be conducted to estimate the incidence rates of first VTE in patients with cancer, and the incidence rates of recurrent VTE and all-cause mortality in patients with cancer-associated VTE, presented by cancer type. The cumulative risk of recurrent VTE over time will be derived accounting for mortality as a competing risk.

Health Outcomes to be Measured

Cancer-associated venous thromboembolism All-cause mortality

Collaborators

Carlos Martinez - Chief Investigator - Institute for Epidemiology, Statistics and Informatics GmbH (Pharma Epi)
Alexander Cohen - Collaborator - King's College London (KCL)
Anja Katholing - Collaborator - Institute for Epidemiology, Statistics and Informatics GmbH (Pharma Epi)

Linkages

HES Admitted Patient Care;ONS Death Registration Data;Patient Level Index of Multiple Deprivation;Practice Level Index of Multiple Deprivation