Estimating the risk of acute kidney injury associated with use of diuretics and renin angiotensin aldosterone system blockers in CPRD

Date of Approval
Application Number
Technical Summary

The overall aim of the study is to determine whether the incidence of acute kidney injury (AKI) in patients with chronic conditions (hypertension, heart disease, diabetes and kidney disease) is related to prescribing of diuretics and/or renin angiotensin aldosterone system (RAAS) blockers. We will assess a cohort of patients with the aforementioned chronic conditions who are registered in the Clinical Practice Research Datalink (CPRD), and have taken RAAS blockers, diuretics, and/or a combination of these medications (exposed) and patients who have not taken any of these medications (unexposed). We will conduct Cox regression to determine the association between receiving a prescription of diuretics and/or RAAS blockers with the risk of AKI, and propensity score matching, prior event rate ratio and instrumental variables analyses to adjust for unmeasured confounding.

Health Outcomes to be Measured

Incidence of Acute Kidney Injury


Fergus Caskey - Chief Investigator - University of Bristol
Kate Tilling - Collaborator - University of Bristol
Penny Whiting - Collaborator - University of Bristol
Theresa Redaniel - Collaborator - University of Bristol
Tim Jones - Collaborator - University of Bristol
Yoav Ben-Shlomo - Collaborator - University of Bristol


HES Admitted Patient Care;Patient Level Index of Multiple Deprivation;Practice Level Index of Multiple Deprivation;Other