We aim to estimate the prevalence and incidence of bone infection (osteomyelitis) and joint infection (such as septic arthritis) in a UK population based on CPRD and to characterise their epidemiology in terms of healthcare resource use. Our special interest is in the type of pathogen responsible for the infection where recorded, with the aim of informing future treatments.
Acceptable patients eligible for linkage to HES data and having an ICD-10 code indicative of osteomyelitis or direct infection of a joint will be selected. NHS resource use (primary care consultations, prescriptions, outpatient appointments and inpatient admissions) and associated costs will be characterised. Prior comorbidities will be determined in Aurum using prodcode and medcode classifications.
Period prevalence will be calculated for 2019, based on patients registered at 31st December 2018. We will also calculate the incidence of osteomyelitis and joint infections in 2019. Frequency of healthcare use, as primary-care contacts, inpatient episodes, outpatient attendances, prescriptions issued in primary care, and frequency and type of surgical procedures (via OPCS codes) will be calculated for 2019. Clinical manifestations will be determined in HES from ICD-10 and OPCS codes. Linked HES admitted patient care data will aid the selection of cases and enable analysis of inpatient resource use; HES outpatient data and will enable analysis of outpatient resource use. HES A&E data will enable analysis of resource use.
Prevalence and incidence of osteomyelitis and joint infections; NHS resource use associated with osteomyelitis and joint infections; NHS resource use associated with Gram-negative and Gram positive osteomyelitis and joint infections.
Cerys Jenkins - Chief Investigator - Pharmatelligence Limited t/a Human Data Sciences
Elgan Mathias - Corresponding Applicant - Pharmatelligence Limited t/a Human Data Sciences
Andrew Cooper - Collaborator - Shionogi BV
Ellen Hubbuck - Collaborator - Pharmatelligence Limited t/a Human Data Sciences
Harry Fisher - Collaborator - Pharmatelligence Limited t/a Human Data Sciences
Sara Lopes - Collaborator - Shionogi BV
Stefano Verardi - Collaborator - Shionogi BV
Stephen Marcella - Collaborator - Shionogi Inc