Identifying risk factors associated with having a stroke following an acute exacerbation of COPD (AECOPD)

Date of Approval
Application Number
Technical Summary

We will use CPRD¬-HES-ONS linked data to identify risk factors that that are associated with an increased risk of an acute stroke in the 90-day period immediately following a severe AECOPD. We will use a previously validated algorithm to define a cohort of study-eligible subjects, namely individuals in CPRD with COPD who have experienced at least one severe acute exacerbation of COPD (i.e. have been hospitalised for AECOPD). We will use a combination of a priori knowledge and literature searches to identify a list of potential risk factors. We will then conduct a series of univariable and multivariable logistic regression analyses to assess which of these factors are associated with an increased odds of experiencing a stroke in the period immediately following the onset of an AECOPD.

Health Outcomes to be Measured

Primary outcome: stroke (fatal and non-fatal).


Jennifer Quint - Chief Investigator - Imperial College London
Ann Morgan - Corresponding Applicant - Imperial College London
Chloe Bloom - Collaborator - Imperial College London


HES Admitted Patient Care;ONS Death Registration Data;Patient Level Index of Multiple Deprivation