Long-term severe non-dermatological outcomes in eczema

Date of Approval
Application Number
16_100
Technical Summary

The objectives of this study are to use data from Clinical Practice Research Database (CPRD) and Hospital Episodes Statistics to examine associations between eczema and a range of serious medical outcomes which may be associated with inflammation.
Identifying people with eczema
Populations with eczema will be identified in CPRD using an algorithm currently being developed and validated comprising Read codes and therapies and /or using ICD-10 codes in linked HES data
Eczema and medical outcomes
Several categories of conditions have been hypothesized to be associated with eczema including psychiatric diseases, cardiovascular diseases, fractures and autoimmune diseases. There is a lack of longitudinal population-based data to support the associations.1-9 We will undertake a series of matched cohort studies assessing associations between eczema and each outcome. Specifically, we will assess the associations with psychological diseases and obesity in children and adults (separately) with eczema compared to individuals without eczema. We will also examine if adults with eczema have higher rates of fractures, lymphopenia and acute cardiovascular outcomes.13,34 We will use time-updated Cox regression to compute hazard ratios with 99% confidence intervals to assess the associations between eczema and each outcome. We will examine the robustness of our results using several sensitivity analyses.

Health Outcomes to be Measured

Associations between eczema and psychological diseases Associations between eczema and key medical outcomes

Collaborators

Sinead Langan - Chief Investigator - London School of Hygiene & Tropical Medicine ( LSHTM )
Sinead Langan - Corresponding Applicant - London School of Hygiene & Tropical Medicine ( LSHTM )
Elizabeth Williamson - Collaborator - London School of Hygiene & Tropical Medicine ( LSHTM )
Harriet Forbes - Collaborator - London School of Hygiene & Tropical Medicine ( LSHTM )
Julian Matthewman - Collaborator - London School of Hygiene & Tropical Medicine ( LSHTM )
Katrina Abuabara - Collaborator - University Of California, San Francisco
Liam Smeeth - Collaborator - London School of Hygiene & Tropical Medicine ( LSHTM )
Morten Schmidt - Collaborator - Aarhus University Hospital
Richard Silverwood - Collaborator - University College London ( UCL )
Sigrun Alba Johannesdottir Schmidt - Collaborator - Aarhus University Hospital

Linkages

HES Admitted Patient Care;ONS Death Registration Data;Patient Level Index of Multiple Deprivation;Practice Level Index of Multiple Deprivation