Optimal minimum length of treatment with buprenorphine: A European analysis of medically discontinued opioid dependent patients

Date of Approval
Application Number
16_157
Technical Summary

The primary objective is to estimate the duration of BMAT that results in an optimal stable outcome which will be defined by resource utilization after treatment.

The CPRD database will be accessed for specified subgroups meeting the inclusion and exclusion criteria. The overall healthcare resource utilization and associated costs will be calculated using publically-available NHS sources. Each patient will be categorized into either low or high resource utilization using the median for all patients as a threshold. Each patient will then be assigned to one of six time-treated (on BMAT) cohorts based on the duration of BMAT.

The primary objective of estimating BMAT duration for optimal stable outcome will utilize Fisher’s exact test to analyse differences in proportions between the high and low resource utilization groups across the six time-treated cohorts.

Secondary analyses to support the primary objective will involve studying the relationship between length of BMAT and various subgroup characteristics (age, gender, comorbidities, etc.) and will utilize logistic regression for multivariate analysis of categorical sub-group variables.

Health Outcomes to be Measured

Inpatient, outpatient and accident & emergency hospital visits and associated costs Number of prescriptions in primary care Number of consultations and referrals

Collaborators

Christopher Tyson - Chief Investigator - Applied Healthcare Resource Management Inc - AHRM
Jane Ruby - Collaborator - Reckitt Benckiser Pharmaceutical, Inc

Linkages

HES Accident and Emergency;HES Admitted Patient Care;HES Outpatient