The pattern of incident fractures in patients with diabetes mellitus compared to matched controls

Date of Approval
Application Number
18_275
Technical Summary

The pattern of incident fractures among patients with and without T1DM and T2DM. Within CPRD all patients with a first ever prescription for an insulin or a non-insulin anti-diabetic drug will be selected. Patients will be matched by year of birth, sex and practice to 1 control. Patients with a first ever prescription to an insulin need to have a diagnosis for T1DM before the index date (the date of the first prescription) to be included in our T1DM cohort. Patients with a first ever prescription to a non-insulin anti-diabetic drug need to have a diagnosis of T2DM before the index date to be included in our T2DM cohort. Patients in both cohorts will be followed for incident fractures.

Incidence rates will be calculated by dividing the number of fractures over the number of total person years. Incidence rate ratios will be calculated by dividing the incidence rates for patients with diabetes over the incidence rates of the controls. Fracture and sex specific incidence rates will be calculated. For patients with diabetes incidence rates will be stratified by the presence of diabetes complications at baseline.

Health Outcomes to be Measured

The incidence of various fracture types in diabetes compared to healthy controls in men and women, wherein diabetes will be divided in type I and type II.
- The incidence of various fracture types in diabetic patients with complications versus diabetic patients without complications

Collaborators

Patrick Souverein - Chief Investigator - Utrecht University
Patrick Souverein - Corresponding Applicant - Utrecht University
Cindy Sarodnik - Collaborator - Maastricht University
Frank de Vries - Collaborator - Utrecht University
Johanna Driessen - Collaborator - Utrecht University
Joop van den Bergh - Collaborator - Maastricht University
Nicklas Rasmussen - Collaborator - Aalborg University Hospital
Nicolaas Schaper - Collaborator - Maastricht University
Peter Vestergaard - Collaborator - Aalborg University Hospital
Sandrine Bours - Collaborator - Maastricht University