Predictors of complications of venous thromboembolism

Date of Approval
Application Number
16_018
Technical Summary

Objectives
This study will investigate the predictors for recurrent VTE, bleeding and discontinuation of Vitamin K antagonists (VKA).
Methods
Observational cohort study of patients with a first VTE between January 2008 and March 2015 who are given VKA within 60 days of the initial VTE. The study cohort will be identified through the CPRD and HES.
Data analysis
Multivariate hazard ratios will be derived from Cox regression models comparing patients with the presence of a covariate with those without the covariate. The models will include time-dependent predictors, such as new provoking events or new comorbid conditions. The cohort of patients with a first VTE initially treated with VKAs will form the basis for all analyses.

Collaborators

Carlos Martinez - Chief Investigator - Institute for Epidemiology, Statistics and Informatics GmbH (Pharma Epi)
Alexander Cohen - Collaborator - King's College London (KCL)
Anja Katholing - Collaborator - Institute for Epidemiology, Statistics and Informatics GmbH (Pharma Epi)

Linkages

HES Admitted Patient Care;HES Outpatient;ONS Death Registration Data;Patient Level Index of Multiple Deprivation;Practice Level Index of Multiple Deprivation