Antibiotic use for self-limiting infections can have harmful consequences. These include the development of antibiotic resistance and disruption to the human microbiome, both of which may predispose individuals to further infections which do not respond to antibiotics. Preschool children under 5 years old with respiratory tract infections (RTIs) have the highest rate of antibiotic prescribing for RTIs in primary care, although most RTIs in this age group are self-limiting (viral) illness.
To explore whether higher levels of antibiotic exposure in children is associated with a greater likelihood of subsequent acute respiratory tract infections (RTIs) failing to respond to antibiotic treatment ("response failures")
To examine the relationship between prior antibiotic exposure and antibiotic "response failure" in children presenting with acute RTIs in primary care
The findings of this study will help improve our understanding of the relationship between previous antibiotic exposure for acute, mostly self-limiting RTIs and the development of further acute RTIs which fail to respond to antibiotics. Relating the consequences of unnecessary antibiotic use to more tangible and immediately relevant outcomes rather than to theoretical future harms will help inform the development of more effective educational materials and awareness campaigns to promote appropriate antibiotic prescribing and use.
The findings of this study will help improve our understanding of the relationship between previous antibiotic exposure for acute, mostly self-limiting RTIs in preschool children, and the development of further acute RTIs which fail to respond to antibiotics.
Clare Bankhead - Chief Investigator - University of Oxford
Oliver Van Hecke - Corresponding Applicant - University of Oxford
Alice Fuller - Collaborator - University of Oxford
Christopher Butler - Collaborator - Cardiff University
Kay Wang - Collaborator - University of Oxford
Michael Moore - Collaborator - University of Southampton
Nicholas Francis - Collaborator - Cardiff University
Sara Jenkins-Jones - Collaborator - Pharmatelligence Limited t/a Human Data Sciences