Risk of hypoglycaemia in users of sulphonylureas with renal impairment: a population-based cohort study

Date of Approval
Application Number
16_016
Technical Summary

This study's objective is to evaluate the association between current use of sulphonylurea (SU) only and the risk of hypoglycaemia in relation to renal function, compared with current use of metformin-only. Within the CPRD, all adult patients with at least one prescription for non-insulin antidiabetic agents (NIAA) will be selected. The exposure of interest is use of SUs in patients with type 2 diabetes mellitus (T2DM) and renal impairment (RI). Current SU-only users will be stratified according to their most recent prescribed defined daily dose, most recent renal function and to type of SU (active vs. inactive metabolites).
Exposure will be assessed in a time-dependent manner. Adjusted cox regression models will be used to derive hazard ratios for the association between SU use, renal function and the risk of hypoglycaemia.

Collaborators

Frank de Vries - Chief Investigator - Utrecht University
Andre Krings - Collaborator - Atrium MC
Andrea Burden - Collaborator - ETH Zurich
Hubert Leufkens - Collaborator - Utrecht University
Johanna Driessen - Collaborator - Utrecht University
Judith van Dalem - Collaborator - Utrecht University
Martijn Brouwers - Collaborator - Maastricht University