Inflammatory bowel disease (IBD) is a chronic, relapsing and remitting condition associated with significant morbidity and reduction in quality of life. IBD management has changed significantly in the last two decades. The increased use of biological therapies and widespread uptake of minimally invasive surgery has revolutionised medical and surgical management of IBD patients. These changes are likely to have influenced the number of patients requiring emergency surgery and its associated morbidity and mortality.
There is evidence suggesting socioeconomic status and where patients are treated may be associated with variations in both the treatment received by patients and their outcomes. The Covid-19 pandemic led to an overhaul in service delivery but the reconfiguration of services varied significantly from region to region. The effect of the above, particularly during the pandemic period on IBD patients is unknown.
To establish if emergency admissions and surgery for IBD patients has changed over time due to advances in medical and surgical practice.
To establish how elective surgery delivery has changed over time and how this has been affected by the pandemic.
To investigate if socioeconomic status and geographic region effects the treatment and outcomes of IBD patients.
This will be a retrospective open cohort study of patients who have a known diagnosis of IBD between 2000 and 2021. Patients will be identified using Medcodes for IBD from CPRD and ICD 10 codes from HES data. Surgery will be defined by the OPCS codes from the linked HES data and socioeconomic status from CPRD linked small area data . Mortality will be defined from the Office of National Statistics data.
We will calculate rates of surgery over time using an interrupted time analysis and model them with Poisson regression. We will calculate crude mortality rates and build appropriate Cox proportional hazards regression models.
• Rates of emergency compared to elective surgery over time.
• Differences in adverse outcomes for IBD patients requiring emergency rather than elective surgery. Adverse outcomes will include mortality, length of stay, stoma rates and post operative complications including 30 day re-operation rates.
• The affect of the Covid-19 pandemic on elective and emergency surgery rates.
• Effect of medical treatment on elective and emergency colectomy rates over time.
• Effect of socioeconomic status on adverse outcomes and access to treatment.
• Variation in practice and outcomes between geographic regions.
David Humes - Chief Investigator - University of Nottingham
Jennifer Couch - Corresponding Applicant - Nottingham University Hospitals
Timothy Card - Collaborator - University of Nottingham
Yue Huang - Collaborator - University of Nottingham
HES Admitted Patient Care;ONS Death Registration Data;Patient Level Index of Multiple Deprivation;Practice Level Index of Multiple Deprivation