A recent study demonstrated that in laboratory tests, lansoprazole appears to have potent activity against tuberculosis. Lansoprazole belongs to a class of drugs called proton pump inhibitors and is widely used to treat stomach disorders such as heartburn. It hasn't previously been thought to have any antibiotic properties and is not used to treat infections. Other members of the proton pump inhibitor drug class were not found to have similar properties against tuberculosis. We propose a cohort study, comparing the risk of tuberculosis disease amongst people taking lansoprazole with people taking other proton pump inhibitors. If the results of the laboratory experiments have a useful clinical application, we would expect people taking lansoprazole to have a lower rate of TB. Our findings will be the first clinical evidence of the effect of lansoprazole on active tuberculosis and will help determine whether lansoprazole may be worth investigating further for this indication.
Our overall aim is to assess the effect of lansoprazole on the risk of tuberculosis disease. In order to achieve this we will estimate the relative risk of tuberculosis comparing people prescribed lansoprazole with people prescribed omeprazole or pantoprazole. We will construct a cohort of new users of lansoprazole and new users of omeprazole or pantoprazole and use Cox regression to estimate the hazard ratio for tuberculosis disease.
Ian Douglas - Chief Investigator - London School of Hygiene & Tropical Medicine ( LSHTM )
Krishnan Bhaskaran - Collaborator - London School of Hygiene & Tropical Medicine ( LSHTM )
Laurie Tomlinson - Collaborator - London School of Hygiene & Tropical Medicine ( LSHTM )
Liam Smeeth - Collaborator - London School of Hygiene & Tropical Medicine ( LSHTM )
Sara Thomas - Collaborator - Not from an Organisation
Sinead Langan - Collaborator - London School of Hygiene & Tropical Medicine ( LSHTM )
Thomas Yates - Collaborator - UCL Hospital
HES Admitted Patient Care;HES Outpatient;Patient Level Index of Multiple Deprivation;Practice Level Index of Multiple Deprivation