Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page

Date of Approval Sort ascending Title
01/03/2024 COVID-19 booster vaccine effectiveness in secondary prevention of major adverse cardiovascular events: an emulated target trial in observational data
06/02/2024 Effectiveness of COVID-19 vaccines on severe COVID-19 and post-acute cardiovascular events and diabetes following SARS-CoV-2 infection: A cohort study
29/01/2024 Quantifying the impact of the COVID-19 pandemic and the Kidney Failure Risk Equation on Chronic Kidney Disease care and outcomes in Primary Care
29/12/2023 Retrospective cohort analysis using Clinical Practice Research Datalink (CPRD) linked to Hospital Episode Statistics (HES) to investigate adherence to androgen deprivation therapy (ADT) in patients with prostate cancer
27/12/2023 Epidemiological analysis of inflammatory eye and central nervous system conditions and their risk factors, association with infectious and immune-mediated inflammatory diseases, and health impacts. A UK population-based observational study
15/12/2023 Benefits and risks of pausing long-term osteoporosis treatment: nested case-control and cohort studies using data from the Clinical Practice Research Datalink.
14/12/2023 Incidence and prevalence of Parkinson's: secular and demographic patterns
08/12/2023 Associations between sociodemographic and environmental factors and cardiovascular disease risk in the UK.
07/12/2023 Feasibility study of the occurrence of severe clinical events in steatotic liver disease
07/12/2023 Antipsychotics and Type 2 Diabetes in Children and Young People: A Population-based Study
07/12/2023 Disease epidemiology and drug utilisation for disease-specific treatments of regulatory interest
05/12/2023 Longitudinal Treatment Patterns, Health Outcomes and Costs of Cancer Associated Thrombosis (CAT) in the United Kingdom: A Real-World Study Using Clinical Practice Research Datalink (CPRD)
01/12/2023 Incidence of stroke in patients with epilepsy using anti-seizure medication in England: A retrospective cohort study conducted within the Clinical Practice Research Datalink (CPRD)
30/11/2023 Burden, risk and trends of non-communicable diseases, mortality and hospitalisation among people living with HIV compared to people without HIV
30/11/2023 Use of topiramate and risk of glaucoma: a case-control study in UK primary care
30/11/2023 Understanding the hip and knee osteoarthritis-arthroplasty pathway and improving Day Case Arthroplasty patient selection
30/11/2023 Clinical characteristics, outcomes and disease trajectories for patients with incident atrial fibrillation
30/11/2023 Exploring the risk of cardioMetabolic complications and describing healthcare resource utilisation in PeOple living With ovERweight and obesity: a non-interventional retrospective longitudinal study in the UK. (EMPOWER)
28/11/2023 Incidence of stroke in patients with epilepsy using anti-seizure medication in England: A retrospective cohort study conducted within the Clinical Practice Research Datalink (CPRD)
28/11/2023 Gabapentinoids and the risk of severe exacerbation in Chronic Obstructive Pulmonary Disease