Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page

Approved studies using CPRD Data

Date of Approval Sort ascending Title
23/03/2022 Healthcare Resource Utilisation and Associated Costs in Patients with COVID-19 in England: A Retrospective Cohort Study
18/03/2022 Characterizing long COVID patients across pre-existing physical and mental health conditions: Risk profiling using Electronic Health Records in the United Kingdom
18/03/2022 The impact of COVID-19 pandemic on health care service provision for patients with newly diagnosed cancer
14/03/2022 Psychiatric diagnoses and self-harm episodes among children and young people in UK primary care records before and during the COVID-19 pandemic: a population-based cohort study
14/03/2022 Investigating disruptions in primary care as a result of the COVID-19 pandemic and the introduction of national lockdowns
09/03/2022 Has the incidence of giant cell arteritis in England and Northern Ireland been influenced by the covid-19 pandemic? A case cohort study using CPRD Aurum data
08/03/2022 Variations in the management of Inflammatory Bowel Disease over time: How has Covid-19 effected inflammatory bowel disease patients?
24/02/2022 The Incidence of Common Autoimmune Diseases in People with COVID-19: a Retrospective Cohort Study using the Clinical Practice Research Datalink.
21/02/2022 Post-Authorization Active Surveillance Safety Study Using Secondary Data to Monitor Real-World Safety of Spikevax in Europe
01/02/2022 How the predictions of algorithms used in healthcare provision change: an investigation using COVID-19 and Cardiovascular disease risk prediction case studies.
27/01/2022 An observational retrospective cohort study describing clinical outcomes and utilisation of healthcare resources among persons with COVID-19 in England, stratified by infection severity and selected comorbidities
05/01/2022 Impact of the coronavirus disease (COVID-19) pandemic on incidence of tics in children and young people: a population-based cohort study
23/12/2021 Comparative effectiveness of Umeclidinium+Vilanterol versus Tiotropium Bromide+Olodaterol among patients with Chronic Obstructive Pulmonary Disease in a real-world primary care setting in the UK
23/12/2021 Do features occurring prior to MS diagnosis vary according to background: a nested case control study
23/12/2021 RECORD-HF: A REtrospective COhort study of heart failure-Related outcomes in patients who are prescribed a loop Diuretic without a diagnosis of Heart Failure
23/12/2021 Patterns and clinical outcomes of cardiovascular medication use after a cancer diagnosis in patients with heart failure
23/12/2021 A post-authorisation (post-marketing) observational study using existing secondary health data sources to evaluate the association between exposure to the AstraZeneca COVID-19 vaccine (AZD1222) and safety concerns
22/12/2021 Investigating the conversion rate of routine referrals for patients presenting with symptoms of possible cancer.
22/12/2021 Longitudinal trajectories of work absence in patients with musculoskeletal and, or, mental health conditions
20/12/2021 Risk of major adverse cardiovascular events in patients with elevated low-density lipoprotein cholesterol, excluding atherosclerotic cardiovascular disease, atherosclerotic cardiovascular disease -risk equivalent and familial hypercholesterolemia patients