Research applications

Access to CPRD data is subject to protocol approval by an Independent Scientific Advisory Committee (ISAC) approval is required if access to anonymised patient level data is being requested for research purposes.

This includes access to the following:

For further clarifications please contact the ISAC Secretariat at isac@cprd.com 

View the list of approved studies using CPRD data.

Research protocols

All protocols must be submitted to the ISAC Secretariat using the Protocol Application Form. Applicants should ensure that the latest version of the forms are used. Applications for data access will not be accepted in any other format. In addition, a brief curriculum vitae and conflict of interest statement for each researcher named on the application should be included using the template provided.

The Protocol Application Form, CV template, guidance on completion of the application form and on the content of protocols can be downloaded below.

Completed applications should be sent to the ISAC Secretariat at isac@cprd.com.

The Secretariat will provide a Protocol Number for use in future communications. Applicants will also be provided with CV numbers, which can be used in any future applications.

(Word,158KB, 5 pages)
(PDF, 276KB, 14 pages)
(Word, 37KB, 1 page)

Resubmissions and amendments 

Applicants wanting to resubmit an ISAC Protocol Application, or request and amendment to an approved ISAC protocol, should follow the Guidance on Resubmissions and Amendments below. Resubmissions and amendments should be sent to the ISAC Secretariat at isac@cprd.com.

(PDF, 130KB, 2 pages) 

Feasibility studies

Applicants wishing to submit a Feasibility Study must contact isac@cprd.com to discuss the study prior to submitting an application. Feasibility study applications must be submitted to the ISAC Secretariat using the Feasibility Studies Application Form. Applications will not be accepted in any other format. In addition, a brief curriculum vitae (CV) and conflict of interest statement for each researcher named on the application should be included.

The Feasibility Study Application Form, Application Guidance Notes, and CV template can be downloaded below.

Completed Feasibility Study applications should be sent to the ISAC Secretariat at isac@cprd.com.

The Secretariat will provide a Feasibility Study number for use in future communications.  

 (Word, 301KB, 4 pages) 
(Word, 37KB, 1 page) 
(PDF, 233KB, 9 pages) 

Exemptions

Some uses of data, such as conducting analyses for submissions to regulatory bodies, are exempt from ISAC review. 

Analysis for regulatory bodies 

In general, ISAC approval is required prior to release of CPRD data to any third party, so as to ensure that the standard of studies carried out using CPRD data is maintained. However, there are some types of aggregate data necessary for regulatory work that is suitable for exemption from this requirement, such as:

  • Counts of patients receiving prescriptions for a certain substance;
  • Counts of prescriptions for a certain substance / substances;
  • Distribution of number of prescriptions per patient (mean, median, minimum, maximum, interquartile range etc…);
  • Distribution of prescription duration;
  • Distribution of patient time at risk;
  • Counts of patients with a particular clinical event. 


[Page last reviewed 28 September 2018]