Statins are widely used drugs for hypercholesterinaemia and secondary prevention of cardiovascular diseases. In addition to their ability to reduce cholesterol levels, statins were found to decrease mortality and incidence of several tumours.
The risk of glioma in patients using statins was only investigated in two prior studies, but both of them showed promising inverse relations between statin use and glioma risk. To further the existing evidence, we propose to conduct an analysis using the U.K.-based Clinical Practice Research Datalink (CPRD) to analyse use of statins among cases with glioma and controls without this disease. Cases will be individuals with an incident diagnosis of glioma between 1995 and 2015. We will match ten control patients per case on age, sex, calendar time, general practice, and number of years of active history in the CPRD prior to the index date.
Using data from the CPRD, we intend to perform a 1:10 matched cases control analysis to explore the association between statin use and risk of glioma. Relative risks will be estimated by conducting conditional logistic regression analyses to determine odds ratios (ORs) with 95% confidence intervals (CIs) of glioma in relation to use of statins. Analyses will be adjusted for various potential confounders and only factors altering the risk of glioma by >10% will be included in the final multivariate analysis.
Christoph Meier - Chief Investigator - University of Basel
Claudia Becker - Collaborator - University of Basel
Corinna Seliger - Collaborator - University of Regensburg
Michael Leitzmann - Collaborator - University of Regensburg
Peter Hau - Collaborator - University of Regensburg
Susan Jick - Collaborator - BCDSP - Boston Collaborative Drug Surveillance Program
Ulrich Bogdahn - Collaborator - University of Regensburg
HES Admitted Patient Care