Chronic respiratory diseases (log-standing diseases of the airway) including chronic obstructive pulmonary disease (COPD), asthma, bronchiectasis and IPF are very common, increasing in prevalence and cause significant morbidity and mortality worldwide. Within the UK, people with chronic respiratory disease are at increased risk of death compared to the general population. Previous studies have suggested that the increased mortality is due to cardiovascular and respiratory disease. In people with COPD for example, it is estimated that 1/3 die of respiratory disease, 1/3 of cardiovascular disease and 1/3 of lung cancer. However, whether there have been changes in causes of mortality over the last 10 years in people with COPD and other chronic lung disease has not been studied. This study will investigate changes in causes of mortality for people with chronic respiratory diseases over the last 10 years in the UK.
This study will investigate whether there have been changes in causes of death in people with chronic respiratory diseases (asthma, COPD, bronchiectasis and IPF) over the past 15 years in the UK. We will use linked CPRD, HES and ONS data to investigate changes in causes of death within each chronic respiratory disease over the past 10 years. We will undertake descriptive analyses to investigate changes in causes of death over time. We will analyse rates of death associated with each chronic lung disease stratified by age and gender. Understanding changes in the causes of death overtime in people with chronic respiratory diseases will help us to better understand the way these people are currently managed and to inform us if we should be managing them in a different way. For example, if more people with COPD are now dying of CVD compared to their respiratory disease then it would provide a reason to increase cardiovascular disease prevention and to better understand cardiovascular disease management in this group.
Overall mortality; Disease specific mortality.
Jennifer Quint - Chief Investigator - Imperial College London
Jennifer Quint - Corresponding Applicant - Imperial College London
Benedetta Marchiorello Dal Corno - Collaborator - Imperial College London
Kieran Rothnie - Collaborator - GlaxoSmithKline Services Unlimited (UK)
ONS Death Registration Data;ONS Death Registration Data;ONS Death Registration Data;Patient Level Index of Multiple Deprivation;Patient Level Index of Multiple Deprivation;Patient Level Index of Multiple Deprivation