Lung function tests relate to how well our lungs are working and measure such things as how much air our lungs can hold and how easily we can breathe in and out. All individuals have some decline in their lung function over time, particularly in later life. People with chronic obstructive pulmonary disease (COPD) lose lung function faster than the general population, particularly those who continue to smoke. Lower lung function is associated with premature death and may lead to the inability to perform simple physical tasks such as walking short distances unaided. No studies have looked at the decline in the total volume of air in the lungs of people with COPD. Using statistical models, we will describe how lung function changes in people with COPD over a 14 year time period and look at which groups of patients have the biggest decline.
People with COPD have a faster decline in their lung function than people without COPD. However, little is known about how quickly lung function decline in a primary care cohort in an average COPD patient. Additionally, little is known about the decline in forced vital capacity (FVC). Using a mixed effects linear model, we will investigate decline in lung function in people with prevalent COPD over a 14 year period, we will also model patient characteristics associated with fast or slow lung function decline using logistic regression.
1) Rate of FEV1 and FVC decline in COPD patients
2) Risk of being a fast FEV1 or FVC decliner
Jennifer Quint - Chief Investigator - Imperial College London
Hannah Whittaker - Corresponding Applicant - Imperial College London
Debbie Jarvis - Collaborator - Imperial College London
Jeanne Pimenta - Collaborator - BioMarin Pharmaceutical Inc.
Peter Burney - Collaborator - Imperial College London
Steven Kiddle - Collaborator - AstraZeneca Ltd - UK Headquarters
Hana Mullerova - Collaborator - AstraZeneca Ltd - UK Headquarters
HES Admitted Patient Care;ONS Death Registration Data;Patient Level Index of Multiple Deprivation