Decreased kidney function is a known risk factor for fractures, in particular, the first fracture. It is known that the risk of fractures is increased in subjects with a decreased kidney function as compared to subjects with a normal kidney function. However, it is unknown whether the decreased kidney function is also a risk factor for a second fracture. Therefore, the aim of this study is to evaluate among patients who have sustained a hip fracture, the relation between kidney function and a subsequent non-hip fracture.
The Kidney Disease: Improving Global Outcomes (KDIGO) classification for chronic kidney disease (CKD) consists of 5 stages; G1: estimated glomerular filtration rate (eGFR) > 90ml/min/1.73m2, G2: eGFR 60-89 ml/min/1.73m2, G3: eGFR 30-59 ml/min/1.73m2, G4: eGFR 15 -29 ml/min/1.73m2 and G5: eGFR < 15ml/min/1.73m2.(1) This study`s objective is to evaluate the association between CKD stage G3-G5 and subsequent fragility fracture risk after a first hip fracture. Patients with a first hip fracture and CKD stage G1 and G2 will be the reference group. Within the CPRD, all patients aged 50 years or older with a first hip fracture will be selected. Kidney function will be assessed time-dependently and Cox regression models will be used to estimate the Hazard Ratio of the association between kidney function and subsequent fracture risk. Analyses will be adjusted for lifestyle variables, comorbidities and concomitant drug use.
Risk of fracture; Risk of subsequent fracture.
Frank de Vries - Chief Investigator - Utrecht University
Frank de Vries - Corresponding Applicant - Utrecht University
Caroline Wyers - Collaborator - Maastricht University
Irma de Bruin - Collaborator - Maastricht University
Johanna Driessen - Collaborator - Utrecht University
Joop van den Bergh - Collaborator - Maastricht University
Patrick Souverein - Collaborator - Utrecht University
Piet Geusens - Collaborator - Maastricht University
Tjeerd van Staa - Collaborator - University of Manchester