Many Chronic Obstructive Pulmonary Disease (COPD) patients will have other long-term chronic conditions called co-morbidities that will affect their outcomes, e.g. their survival prospects, how many prescription medicines they are taking and how much they will need care. In turn the presence of these conditions will be depend on risk factors, including age and socioeconomic status. This project aims to characterise typical combinations of conditions, and their relevance to outcomes and risk factors, so that clinicians can tailor a patientÂ’s care to an individual set of co-morbidities. We will make use of profile regression, a statistical technique that can be used to find combinations of conditions that relate to outcomes and risk factors.
We will extract co-morbidities from every Clinical Practice Research Datalink (CPRD) Chronic Obstructive Pulmonary Disease (COPD) patient with linked ONS-HES-IMD data, who are alive in 2012, to allow us to study five-year survival. We will study 36 co-morbidities 1 using definitions created by the Quint group or by the Cambridge CPRD team https://www.phpc.cam.ac.uk/pcu/cprd_cam/codelists/ .
We will extract five-year and one-year mortality using ONS data, treatment burden from CPRD and number of hospitalisations from HES. Profile regression will then be used to identify clusters relevant to mortality, hospitalisations, treatment burden, age and index of multiple deprivation, which will be summarised in heatmaps.
One-year and five-year mortality, treatment burden (number of current prescription medications) and number of hospitalisations.
Steven Kiddle - Chief Investigator - AstraZeneca Ltd - UK Headquarters
Steven Kiddle - Corresponding Applicant - AstraZeneca Ltd - UK Headquarters
Duncan Edwards - Collaborator - University of Cambridge
Hannah Whittaker - Collaborator - Imperial College London
Jennifer Quint - Collaborator - Imperial College London
Paul Kirk - Collaborator - University of Cambridge
Sylvia Richardson - Collaborator - University of Cambridge
Yajing Zhu - Collaborator - University of Cambridge
HES Admitted Patient Care;ONS Death Registration Data;Patient Level Index of Multiple Deprivation