Heart failure (HF) is a common cause of hospitalisation, often prolongs hospital stay and is associated with increased death rates. Substantial differences in patients' characteristics, patient management and outcomes during hospitalisation of HF patients are known to exist between the Western and the Asian countries. However, the studies are limited by middle-sized datasets of HF patients and based on indirect comparisons. Simultaneous access to individual patient-level data in large-scale nationwide databases would enable the outcomes and the treatment strategy of patients with similar attributes in different countries to be compared rather than merely comparing averages based on previous published papers. We propose to evaluate patients with acute (decompensated) heart failure in the UK, USA, Japan and Taiwan.
As a national sample of current practice, we will use linked Clinical Practice Research Datalink (CPRD) data with Hospital Episode Statistics (HES) and Office for National Statistics (ONS) to undertake a cohort study to provide an accurate estimate of the number of people with hospitalised heart failure in the United Kingdom (UK). Japanese data will be sourced from the 2012-2015 Nationwide Claim-Based Database, the Japanese Registry Of All cardiac and vascular Diseases - Diagnosis Procedure Combination (JROAD-DPC), US data from the National Inpatient Sampling Database and Taiwan data from National Health Insurance Research Database -NHIRD. Each cohort (UK, USA, Japan and Taiwan) will be analysed separately. All-cause mortality, length of hospital and health care resource utilisation will be analysed in each dataset. On completion of the analysis, pooled estimates will be compared across the datasets.
All-cause mortality
Length of hospital stay
30 day readmissions
Health care resource utilization
Jennifer Quint - Chief Investigator - Imperial College London
Varun Sundaram - Corresponding Applicant - Imperial College London
Claudia Gulea - Collaborator - Imperial College London
Toshiyuki Nagai - Collaborator - Imperial College London
HES Admitted Patient Care;ONS Death Registration Data