The aim of this study is to describe the differences in complications and death in men and women with both chronic obstructive pulmonary disease (a chronic lung disease mostly caused by smoking) and peripheral arterial disease (a disease of the arteries that causes circulation problems and reduced blood flow to the legs). It is known that peripheral arterial disease is common in people with chronic obstructive pulmonary disease, but it is not known how differences in outcomes (complications such as limb pain and lack of blood flow or death) are different between men and women. We will describe baseline characteristics in men and women with chronic obstructive pulmonary disease and peripheral arterial disease in terms of co-morbidities, management of and severity of chronic obstructive pulmonary disease as well as differences in all cause and cardiovascular specific mortality, and complications of peripheral arterial disease arising such as acute limb blood flow problems and procedures to fix these. We think that we will find that there are differences in the characteristics of men and women with chronic obstructive pulmonary disease and peripheral arterial disease as well as the way in which they are managed and their outcomes.
The aim of this study is to describe the differences in morbidity and mortality in men and women with both chronic obstructive pulmonary disease (COPD) and peripheral arterial disease (PAD) as they commonly co-occur. The study will be undertaken utilizing linked data within the Clinical Practice Research Datalink GOLD and Aurum databases with Hospital Episode Statistics (HES) and Office for National Statistics (ONS) databases. We will describe baseline characteristics in the two groups (including demographics, health behaviours (e.g. smoking), co-morbidities, treatment for COPD, and COPD severity) and compare all-cause mortality and cause specific mortality (cardiovascular) between the two groups using Cox proportional hazard models. We will also compare management and complications in the two groups including drug treatments and revascularisation procedures, major cardiovascular events and acute limb ischaemia.
The primary outcome is all-cause mortality
The secondary outcomes are 1)Cardiovascular specific mortality 2) acute limb ischaemia
Jennifer Quint - Chief Investigator - Imperial College London
Jennifer Quint - Corresponding Applicant - Imperial College London
Laura Portas - Collaborator - Imperial College London
HES Admitted Patient Care;ONS Death Registration Data;Patient Level Index of Multiple Deprivation