This study focusses on patients with coronary artery disease (CAD), peripheral artery disease (PAD), and both CAD and PAD. The aim of the study is to estimate how frequent each of these conditions are in England, what issues and challenges patients with these conditions frequently face, and how much it costs the National health Service to treat patients with these conditions. We will also look at the implications on patients of these three disorders who also suffer from other diseases such as diabetes or who have had a heart attack in the past.
This is a cohort study with the overall objective of gaining a better understanding of the epidemiology, disease course, health resource utilisation (HRU), and treatment patterns of real-world patients with coronary artery disease (CAD), peripheral artery disease (PAD), and CAD/PAD. The specific aims of the study are:
• To estimate the incidence and prevalence of CAD, PAD, and CAD/PAD
• To describe demographic and clinical characteristics of patients with CAD, PAD, and CAD/PAD
• To estimate the risk/incidence of complications (e.g. major cardiovascular events, bleeding) among patients with CAD, PAD, and CAD/PAD
• To describe HRU related to CAD and PAD complications among patients with CAD, PAD and CAD/PAD
• To describe treatment patterns, with a focus on standard of care, among patients with CAD, PAD, and CAD/PAD
• To estimate the risk/incidence of complications, compare the risk of complications, describe HRU related to CAD and PAD complications, and describe treatment patterns among subgroups of patients with CAD, PAD, and CAD/PAD defined by demographics, medical history, prior procedures, medication use, and risk scores
The study will be undertaken utilizing linked data within the Clinical Practice Research Database and Hospital Episode Statistics database. The study time frame will be 1 January 2010 to the most recent data available.
Incidence and prevalence of coronary artery disease (CAD), peripheral artery disease (PAD), and CAD and PAD
• Risk and incidence of complications (e.g. major cardiovascular events, bleeding) among patients with CAD, PAD, and CAD and PAD
• Health resource utilisation (HRU) related to CAD and PAD complications in patients with CAD, PAD, and CAD and PAD
• Treatment patterns (with a focus on standard of care) in patients with CAD, PAD, and CAD and PAD
• Risk/incidence of complications for CAD and PAD, HRU for CAD and Pad complications, and treatment patterns for key sub-populations of patients with CAD, PAD, and CAD and PAD
Jessica Jalbert - Chief Investigator - Regeneron Pharmaceuticals, Inc.
Jessica Jalbert - Corresponding Applicant - Regeneron Pharmaceuticals, Inc.
Alexander Cohen - Collaborator - King's College London (KCL)
Jean Baptiste Briere - Collaborator - Bayer AG
Jennifer Quint - Collaborator - Imperial College London
Julian Halcox - Collaborator - Swansea University
HES Accident and Emergency;HES Admitted Patient Care;HES Outpatient;ONS Death Registration Data;Practice Level Index of Multiple Deprivation