This study focusses on patients with coronary artery disease (CAD) and chronic heart failure (CHF). CAD is known to be the leading cause of death in people globally, and is responsible for 30% of all deaths in persons aged 35 and above. In addition, CHF is also known to be responsible for a large number of deaths and hospitalisations, with over 150,000 hospitalisations due to CHF occurring in the UK each year. Given this, it would be of great value to understand how many people in the UK are living with CAD, CHF, and CAD and CHF. The aim of the study is to estimate how frequent each of these conditions are in England, what issues and challenges patients with these conditions frequently face, and how much it costs the National health Service to treat patients with these conditions. We will also look at the implications on patients of these three disorders who also suffer from other diseases such as diabetes or who have had a heart attack in the past.
This is a cohort study with the overall objective of gaining a better understanding of the epidemiology, disease course, health resource utilisation (HRU), and treatment patterns of real-world patients with Chronic heart failure (CHF), and patients with CAD and CHF. The specific aims of the study are:
- To estimate the incidence and prevalence of CHF, CAD and CHF
- To describe demographic and clinical characteristics of patients with CHF, and patients with CAD and CHF
- To estimate the risk/incidence of complications (e.g. major cardiovascular events, bleeding) among patients with CHF, CAD and CHF
- To describe HRU related to CAD and CHF complications among patients with CHF, CAD and CHF
- To describe treatment patterns, with a focus on standard of care, among patients with CHF and patients with CAD and CHF
- To estimate the risk/incidence of complications, compare the risk of complications, describe HRU related to CHF and CAD/CHF complications, and describe treatment patterns among subgroups of patients with CHF, and patients with CAD and CHF defined by demographics, medical history, prior procedures, medication use, and risk scores.
The study will be undertaken utilizing linked data within the Clinical Practice Research Database and Hospital Episode Statistics database. The study time frame will be 1 January 2006 to the most recent data available.
Incidence and prevalence of coronary artery disease (CAD), peripheral artery disease (PAD), and CAD and PAD.
Risk and incidence of complications (e.g. major cardiovascular events, bleeding) among patients with CAD, PAD, and CAD and PAD
Health resource utilisation (HRU) related to CAD and PAD complications in patients with CAD, PAD, and CAD and PAD
Treatment patterns (with a focus on standard of care) in patients with CAD, PAD, and CAD and PAD
Risk/incidence of complications for CAD and PAD, HRU for CAD and Pad complications, and treatment patterns for key sub-populations of patients with CAD, PAD, and CAD and PAD
Jennifer Quint - Chief Investigator - Imperial College London
Varun Sundaram - Corresponding Applicant - Imperial College London
Alexander Cohen - Collaborator - King's College London (KCL)
Amitava Banerjee - Collaborator - University College London ( UCL )
Jean Baptiste Briere - Collaborator - Bayer AG
Julian Halcox - Collaborator - Swansea University
HES Accident and Emergency;HES Admitted Patient Care;HES Outpatient;Patient Level Index of Multiple Deprivation