Autoimmune hepatitis is a chronic liver disease caused by a dysfunctional immune system. Information about the occurrence of autoimmune hepatitis is necessary for understanding the burden of the disease. The UK Clinical Practice Research Database provide a unique opportunity to find such information. This project will determine the occurrence of autoimmune hepatitis in the UK over a 26 year period and describe the trends therein. This study will give insights into the distribution of disease in terms of age, sex, geography and time.
Using data from the Clinical Practice Research Database in the UK, the objective of this study is to estimate the incidence and prevalence of autoimmune hepatitis in the UK. We will use a validated method of ascertaining people with autoimmune hepatitis to quantify the incidence and prevalence of the disease. We will also describe the variation in these measures of disease occurrence by various sociodemographic characteristics.
An AIH diagnosis will be defined by a record of one or more of the Read codes of AIH (and in subset analyses; by one or more of the Read codes of AIH and/ or ICD-10 codes of AIH) as listed in appendix A. Diagnostic criteria for AIH are well-established, and the sensitivity of the coded diagnosis for AIH (using the exact same Read codes as in the provided study) for detection of this condition in general practice and therefore in the CPRD is 89%. In the proposed study, three cohorts of patients with AIH will be defined with the most restrictive cohort III representing the lowest believable number of AIH cases. In a supplemental analysis, we will also assess whether there are cases only identified in HES. Data source/s: Codes for inclusion and exclusion will be obtained from the CPRD and HES. Test results regarding viral hepatitis will be obtained from the CPRD. Dates and fact of death will be obtained from the CPRD. IMD scores for included patients will be obtained by linking CPRD data to deprivation data from 1997 to 2016. The IMD score will defined by quintiles at General Practice level for the obtained data.
Joe West - Chief Investigator - University of Nottingham
Lisbet Gronbaek - Corresponding Applicant - Aarhus University Hospital
Colin Crooks - Collaborator - University of Nottingham
Harmony Otete - Collaborator - University Of Central Lancashire
Peter Jepsen - Collaborator - Aarhus University Hospital
Timothy Card - Collaborator - University of Nottingham
HES Admitted Patient Care;HES Outpatient;ONS Death Registration Data;Patient Level Index of Multiple Deprivation;Practice Level Index of Multiple Deprivation