Endometriosis is a common condition effecting the reproductive system, it is caused when the lining of the womb grows in other places. Approximately 1 in 10 people who have periods will have endometriosis. People with endometriosis suffer from chronic pelvic (lower back and stomach) pain and may have issues with fertility. This work will calculate how many people are diagnosed with endometriosis each year (2010-2020), we will use both GP and hospital records. We will try to investigate whether the average age of diagnosis has changed, whether endometriosis is diagnosed more in certain regions. We will also investigate if endometriosis is more common in certain ethnic groups as well as if endometriosis is more common in people who are over or underweight.
This work will have significant public health benefits, as we will demonstrate how many people have endometriosis which will be important to guide and inform the provision of health care services.
There has been no recent analyses of the prevalence and incidence of endometriosis, this lack of up-to-date data means that it is difficult to accurately allocate resources given the current population who suffer from endometriosis. Endometriosis is a fibrotic disease, meaning that because of chronic inflammation, fibrotic lesions may present in the uterus. Endometriosis has been included in previous analyses of fibrotic diseases which have used electronic healthcare records to try to understand whether there is an underlying fibrotic mechanism which can lead to a person suffering from multiple fibrotic conditions (fibrotic multimorbidity).
This work looks to estimate both the incidence and prevalence of endometriosis in England using data from CPRD Aurum linked with Hospital Episode Statistics (HES) and IMD data. We will describe the temporal trends in the annual calculations of incidence and prevalence of endometriosis over the past decade (2010 to 2020). More specifically, we will use HES Admitted Patient Care (APC) data and CPRD Aurum data to identify endometriosis and subsequently compare the incidence and prevalence of endometriosis diagnosed in primary care compared with the incidence and prevalence of endometriosis recorded in HES APC as well as the incidence and prevalence of the condition recorded in both CPRD Aurum and HES APC, and the incidence/ prevalence of endometriosis recorded in CPRD Aurum or HES APC. Annual endometriosis incidence and prevalence will be stratified by age, region, socioeconomic status (using IMD data), ethnicity and BMI.
This work will have significant public health benefits, as we will demonstrate how many people have endometriosis which will be important to guide and inform the provision of health care services.
Incidence and prevalence of endometriosis diagnosed in primary and secondary care records
Jennifer Quint - Chief Investigator - Imperial College London
Georgie Massen - Corresponding Applicant - Imperial College London
Olivia Blamires - Collaborator - Imperial College London
HES Admitted Patient Care;Patient Level Index of Multiple Deprivation