People who smoke are at increased risk of developing certain diseases (such as heart disease or stroke or certain cancers) and of dying at a younger age than people who dont smoke. In this study we will quantify that risk by comparing a group of people who do or have smoked with those who do not and compare the development of certain diseases in both groups as well as death rates.
Smoking causes significant morbidity and mortality. In this cohort study we will use Cox regression to compare a group of smokers (current and ex) to never smokers and investigate differences in the incidence of certain cancers (lung, oropharynx, larynx, oesophagus, acute myeloid leukaemia, stomach, liver, pancreas, kidney and ureter, bladder, cervix and colorectal) as well as other diseases (ischaemic heart disease, stroke, abdominal aortic aneurysm, pneumonia, COPD, and diabetes) to try and ascertain how smoking may impact on morbidity and mortality. This information will feed into the smoking report currently being commissioned by the Royal College of Physicians. We are aware that this cohort study is not all encompassing but instead we have chosen a number of representative diseases to study.
Jennifer Quint - Chief Investigator - Imperial College London
Jennifer Quint - Corresponding Applicant - Imperial College London
Ann Morgan - Collaborator - Imperial College London
ONS Death Registration Data;Patient Level Index of Multiple Deprivation