Diabetes is a condition where the body cannot control the blood sugar level. Compared to people without diabetes, people with diabetes are more likely to develop diseases in the heart and blood vessels (i.e. cardiovascular diseases), kidney, nerves and eyes, and have a higher risk of death.
In the last two decades there have been significant improvements in the treatment of diabetes. This has resulted in a reduced risk of death and therefore a longer life expectancy compared to people who received a diagnosis of diabetes in 1980s and 1990s. However, a reduced mortality also occurred in people without diabetes; as such, it is not clear, particularly in UK, whether the improvement has been greater in people with or without diabetes.
This study aims to examine the risk of death in people with and without diabetes over the last two decades and assess whether the risk of death improved equally in people with and without diabetes.
Using data collected in the Clinical Practice Research Datalink (CPRD) Gold database with linkage to Hospital Episode Statistics (HES) and Office for National Statistics (ONS), we will investigate changes in the mortality rate of diabetic patients in the time period 1998 - 2018 and compare these to non-diabetic patients. The cohort will include diabetic participants identified within CPRD (exposed participants) along with a randomly selected sample of one million non-diabetic patients (non-exposed participants). The outcomes are all-cause, cardiovascular and cancer deaths, identified via linkage to ONS. All-cause and cause-specific (cardiovascular and cancer) mortality rates will be estimated by age, sex, and calendar time in subjects with and without diabetes; then, rate ratio and rate differences between people without and without diabetes will be quantified.
All-cause mortality
- Cardiovascular mortality
- Cancer mortality
Francesco Zaccardi - Chief Investigator - University of Leicester
Francesco Zaccardi - Corresponding Applicant - University of Leicester
Claire Lawson - Collaborator - University of Leicester
Joanne Miksza - Collaborator - University of Leicester
Kamlesh Khunti - Collaborator - University of Leicester
Melanie Davies - Collaborator - University of Leicester
Suping Ling - Collaborator - University of Leicester
HES Admitted Patient Care;ONS Death Registration Data;Patient Level Index of Multiple Deprivation