As medical care has improved, more people are surviving cancer, and the number of survivors is growing. Cancer and its treatment may have an effect on the health of survivors throughout their life. There is thought to be a link between having a history of cancer and an increased chance of developing diseases that affect the heart and blood vessels (known as cardiovascular diseases, or CVD). Some studies have looked at how specific cancer treatments affect the chances of developing CVD, but there is a need for a comprehensive study covering a range of cancer types and cardiovascular outcomes. This study aims to find out how much a history of cancer affect the chances of developing CVD, for different types of cancer and cardiovascular disease. This will be investigated by comparing cancer survivors to similar individuals, but with no history of cancer, using medical records from primary care linked to national cancer and other databases. Our study will help to identify cancers that lead to a particularly high chance of getting certain cardiovascular diseases, which may help health services target interventions to prevent CVD, and will help identify priority areas for more detailed research on how specific cancers can lead to CVD.
As medical care has improved, an increasing number of individuals are surviving cancer, and the population of survivors is growing. Cancer and its treatment may impact on the health of survivors throughout life, and there is evidence for an association between having a history of cancer and an increased risk of cardiovascular diseases (CVD). Some studies have looked at how specific cancer treatments affect the chances of developing CVD, but there is a need for a comprehensive study covering a range of cancer types and cardiovascular outcomes. This study will use survival analysis methods within a matched cohort study design; cancer survivors will be compared to controls with no history of cancer, and associations between site-specific cancer history and risks of a range of cardiovascular diseases will be estimated. This will help identify cancers that lead to a particularly high risk of certain cardiovascular diseases, and help identify priority areas for future research in cardio-oncology.
- Cardiovascular diseases (coronary artery disease, arrhythmia, venous thromboembolism, cerebrovascular disease, other). - Cause-specific death (cardiovascular vs cancer vs other).
Krishnan Bhaskaran - Chief Investigator - London School of Hygiene & Tropical Medicine ( LSHTM )
Krishnan Bhaskaran - Corresponding Applicant - London School of Hygiene & Tropical Medicine ( LSHTM )
Alexander Richard Lyon - Collaborator - Imperial College London
Anthony Matthews - Collaborator - London School of Hygiene & Tropical Medicine ( LSHTM )
Claire Lawson - Collaborator - University of Leicester
Helen Strongman - Collaborator - London School of Hygiene & Tropical Medicine ( LSHTM )
Isabel dos-Santos-Silva - Collaborator - London School of Hygiene & Tropical Medicine ( LSHTM )
Liam Smeeth - Collaborator - London School of Hygiene & Tropical Medicine ( LSHTM )
Michael Sweeting - Collaborator - University of Leicester
Sarah Gadd - Collaborator - London School of Hygiene & Tropical Medicine ( LSHTM )
Susannah Stanway - Collaborator - Royal Marsden Hospital
Umesh Kadam - Collaborator - University of Leicester
HES Admitted Patient Care;NCRAS Cancer Registration Data;ONS Death Registration Data;Patient Level Index of Multiple Deprivation;Patient Level Index of Multiple Deprivation;Practice Level Index of Multiple Deprivation