Bibliography

Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,500 peer-reviewed publications. The CPRD bibliography is updated on a monthly basis (last updated 5 June 2020) and papers are listed below and in the PDF below.

If you have published papers using CPRD data which are not included in this list, please contact us at enquiries@cprd.com so that we can update the bibliography.

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This work uses data provided by patients and collected by the NHS as part of their care and support. CPRD encourages researchers to use this citation in all publications using CPRD data. Find out more about acknowledging the use of patient data at the Understanding Patient Data website. 

 

 

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Author Title Type [ Year(Asc)]
Filters: Author is Leufkens, H. G.  [Clear All Filters]
2017
J. H. Driessen, van den Bergh, J. P., van Onzenoort, H. A., Henry, R. M., Leufkens, H. G., and de Vries, F., “Long-term use of dipeptidyl peptidase-4 inhibitors and risk of fracture: A retrospective population-based cohort study”, Diabetes Obes Metab, vol. 19, pp. 421-428, 2017.
B. Spaetgens, de Vries, F., Driessen, J. H. M., Leufkens, H. G., Souverein, P. C., Boonen, A., van der Meer, J. W. M., and Joosten, L. A. B., “Risk of infections in patients with gout: a population-based cohort study”, Sci Rep, vol. 7, p. 1429, 2017.
L. M. Knapen, de Jong, R. G., Driessen, J. H., Keulemans, Y. C., van Erp, N. P., De Bruin, M. L., Leufkens, H. G., Croes, S., and de Vries, F., “Use of incretin agents and risk of acute and chronic pancreatitis: A population-based cohort study”, Diabetes Obes Metab, vol. 19, pp. 401-411, 2017.
2016
A. M. Gallagher, Williams, T., Leufkens, H. G., and de Vries, F., “The Impact of the Choice of Data Source in Record Linkage Studies Estimating Mortality in Venous Thromboembolism”, PLoS One, vol. 11, p. e0148349, 2016.
P. J. Peeters, Bazelier, M. T., Leufkens, H. G., Auvinen, A., van Staa, T. P., de Vries, F., and De Bruin, M. L., “Insulin glargine use and breast cancer risk: Associations with cumulative exposure”, Acta Oncol, vol. 55, pp. 851-8, 2016.
C. Klop, de Vries, F., Bijlsma, J. W., Leufkens, H. G., and Welsing, P. M., “Predicting the 10-year risk of hip and major osteoporotic fracture in rheumatoid arthritis and in the general population: an independent validation and update of UK FRAX without bone mineral density”, Ann Rheum Dis, vol. 75, pp. 2095-2100, 2016.
J. van Dalem, Brouwers, M. C., Stehouwer, C. D., Krings, A., Leufkens, H. G., Driessen, J. H., de Vries, F., and Burden, A. M., “Risk of hypoglycaemia in users of sulphonylureas compared with metformin in relation to renal function and sulphonylurea metabolite group: population based cohort study”, Bmj, vol. 354, p. i3625, 2016.
L. M. Knapen, van Dalem, J., Keulemans, Y. C., van Erp, N. P., Bazelier, M. T., De Bruin, M. L., Leufkens, H. G., Croes, S., Neef, C., de Vries, F., and Driessen, J. H., “Use of incretin agents and risk of pancreatic cancer: a population-based cohort study”, Diabetes Obes Metab, vol. 18, pp. 258-65, 2016.
2015
C. Klop, Gibson-Smith, D., Elders, P. J., Welsing, P. M., Leufkens, H. G., Harvey, N. C., Bijlsma, J. W., van Staa, T. P., and de Vries, F., “Anti-osteoporosis drug prescribing after hip fracture in the UK: 2000-2010”, Osteoporos Int, vol. 26, pp. 1919-28, 2015.
J. H. Driessen, Henry, R. M., van Onzenoort, H. A., Lalmohamed, A., Burden, A. M., Prieto-Alhambra, D., Neef, C., Leufkens, H. G., and de Vries, F., “Bone fracture risk is not associated with the use of glucagon-like peptide-1 receptor agonists: a population-based cohort analysis”, Calcif Tissue Int, vol. 97, pp. 104-12, 2015.
H. A. van den Ham, Klungel, O. H., Singer, D. E., Leufkens, H. G., and van Staa, T. P., “Comparative Performance of ATRIA, CHADS2, and CHA2DS2-VASc Risk Scores Predicting Stroke in Patients With Atrial Fibrillation: Results From a National Primary Care Database”, J Am Coll Cardiol, vol. 66, pp. 1851-9, 2015.
J. P. Yska, van Roon, E. N., de Boer, A., Leufkens, H. G., Wilffert, B., de Heide, L. J., de Vries, F., and Lalmohamed, A., “Remission of Type 2 Diabetes Mellitus in Patients After Different Types of Bariatric Surgery: A Population-Based Cohort Study in the United Kingdom”, JAMA Surg, vol. 150, pp. 1126-33, 2015.
P. J. Peeters, Bazelier, M. T., Leufkens, H. G., de Vries, F., and De Bruin, M. L., “The risk of colorectal cancer in patients with type 2 diabetes: associations with treatment stage and obesity”, Diabetes Care, vol. 38, pp. 495-502, 2015.
J. V. Been, Szatkowski, L., van Staa, T. P., Leufkens, H. G., van Schayck, O. C., Sheikh, A., de Vries, F., and Souverein, P., “Smoke-free legislation and the incidence of paediatric respiratory infections and wheezing/asthma: interrupted time series analyses in the four UK nations”, Sci Rep, vol. 5, p. 15246, 2015.
2014
V. Abbing-Karahagopian, Huerta, C., Souverein, P. C., de Abajo, F., Leufkens, H. G., Slattery, J., Alvarez, Y., Miret, M., Gil, M., Oliva, B., Hesse, U., Requena, G., de Vries, F., Rottenkolber, M., Schmiedl, S., Reynolds, R., Schlienger, R. G., de Groot, M. C., Klungel, O. H., van Staa, T. P., van Dijk, L., Egberts, A. C., Gardarsdottir, H., and De Bruin, M. L., “Antidepressant prescribing in five European countries: application of common definitions to assess the prevalence, clinical observations, and methodological implications”, Eur J Clin Pharmacol, vol. 70, pp. 849-57, 2014.
C. Klop, Welsing, P. M., Cooper, C., Harvey, N. C., Elders, P. J., Bijlsma, J. W., Leufkens, H. G., and de Vries, F., “Mortality in British hip fracture patients, 2000-2010: a population-based retrospective cohort study”, Bone, vol. 66, pp. 171-7, 2014.
S. Pouwels, de Boer, A., Leufkens, H. G., Weber, W. E., Cooper, C., and de Vries, F., “Risk of fracture in patients with Charcot-Marie-Tooth disease”, Muscle Nerve, vol. 50, pp. 919-24, 2014.
S. Pouwels, de Boer, A., Leufkens, H. G., Weber, W. E., Cooper, C., van Staa, T. P., and de Vries, F., “Risk of fracture in patients with Guillain-Barre syndrome”, Osteoporos Int, vol. 25, pp. 1845-51, 2014.
S. Pouwels, de Boer, A., Leufkens, H. G., Weber, W. E., Cooper, C., van Onzenoort, H. A., and de Vries, F., “Risk of fracture in patients with muscular dystrophies”, Osteoporos Int, vol. 25, pp. 509-18, 2014.
D. Gibson-Smith, Klop, C., Elders, P. J., Welsing, P. M., van Schoor, N., Leufkens, H. G., Harvey, N. C., van Staa, T. P., and de Vries, F., “The risk of major and any (non-hip) fragility fracture after hip fracture in the United Kingdom: 2000-2010”, Osteoporos Int, vol. 25, pp. 2555-63, 2014.
P. J. Peeters, Bazelier, M. T., Uitdehaag, B. M., Leufkens, H. G., De Bruin, M. L., and de Vries, F., “The risk of venous thromboembolism in patients with multiple sclerosis: the Clinical Practice Research Datalink”, J Thromb Haemost, vol. 12, pp. 444-51, 2014.
J. H. Driessen, van Onzenoort, H. A., Henry, R. M., Lalmohamed, A., van den Bergh, J. P., Neef, C., Leufkens, H. G., and de Vries, F., “Use of dipeptidyl peptidase-4 inhibitors for type 2 diabetes mellitus and risk of fracture”, Bone, vol. 68, pp. 124-30, 2014.
2013
S. Pouwels, de Boer, A., Javaid, M. K., Hilton-Jones, D., Verschuuren, J., Cooper, C., Leufkens, H. G., and de Vries, F., “Fracture rate in patients with myasthenia gravis: the general practice research database”, Osteoporos Int, vol. 24, pp. 467-76, 2013.
H. A. van den Ham, Klungel, O. H., Leufkens, H. G., and van Staa, T. P., “The patterns of anticoagulation control and the risk of stroke, bleeding and mortality in patients with non-valvular atrial fibrillation”, J Thromb Haemost, vol. 11, pp. 107-15, 2013.
A. Lalmohamed, Macgregor, A. J., de Vries, F., Leufkens, H. G., and van Staa, T. P., “Patterns of risk of cancer in patients with metal-on-metal hip replacements versus other bearing surface types: a record linkage study between a prospective joint registry and general practice electronic health records in England”, PLoS One, vol. 8, p. e65891, 2013.
M. T. Bazelier, de Vries, F., Vestergaard, P., Herings, R. M., Gallagher, A. M., Leufkens, H. G., and van Staa, T. P., “Risk of fracture with thiazolidinediones: an individual patient data meta-analysis”, Front Endocrinol (Lausanne), vol. 4, p. 11, 2013.
2012
A. Lalmohamed, Bazelier, M. T., van Staa, T. P., Uitdehaag, B. M., Leufkens, H. G., de Boer, A., and de Vries, F., “Causes of death in patients with multiple sclerosis and matched referent subjects: a population-based cohort study”, Eur J Neurol, vol. 19, pp. 1007-14, 2012.
M. T. Bazelier, Mueller-Schotte, S., Leufkens, H. G., Uitdehaag, B. M., Van Staa, T., and de Vries, F., “Risk of cataract and glaucoma in patients with multiple sclerosis”, Mult Scler, vol. 18, pp. 628-38, 2012.
M. T. Bazelier, van Staa, T. P., Uitdehaag, B. M., Cooper, C., Leufkens, H. G., Vestergaard, P., Bentzen, J., and de Vries, F., “A simple score for estimating the long-term risk of fracture in patients with multiple sclerosis”, Neurology, vol. 79, pp. 922-8, 2012.
H. J. de Jong, Klungel, O. H., van Dijk, L., Vandebriel, R. J., Leufkens, H. G., van der Laan, J. W., Tervaert, J. W. Cohen, and Van Loveren, H., “Use of statins is associated with an increased risk of rheumatoid arthritis”, Ann Rheum Dis, vol. 71, pp. 648-54, 2012.
2011
A. M. Gallagher, Smeeth, L., Seabroke, S., Leufkens, H. G., and van Staa, T. P., “Risk of death and cardiovascular outcomes with thiazolidinediones: a study with the general practice research database and secondary care data”, PLoS One, vol. 6, p. e28157, 2011.
M. T. Bazelier, Van Staa, T., Uitdehaag, B. M., Cooper, C., Leufkens, H. G., Vestergaard, P., Bentzen, J., and de Vries, F., “The risk of fracture in patients with multiple sclerosis: the UK general practice research database”, J Bone Miner Res, vol. 26, pp. 2271-9, 2011.
2009
T. P. van Staa, Leufkens, H. G., Zhang, B., and Smeeth, L., “A comparison of cost effectiveness using data from randomized trials or actual clinical practice: selective cox-2 inhibitors as an example”, PLoS Med, vol. 6, p. e1000194, 2009.
2008
E. Setakis, Leufkens, H. G., and van Staa, T. P., “Changes in the characteristics of patients prescribed selective cyclooxygenase 2 inhibitors after the 2004 withdrawal of rofecoxib”, Arthritis Rheum, vol. 59, pp. 1105-11, 2008.
T. P. van Staa, Rietbrock, S., Setakis, E., and Leufkens, H. G., “Does the varied use of NSAIDs explain the differences in the risk of myocardial infarction?”, J Intern Med, vol. 264, pp. 481-92, 2008.
T. P. van Staa, Smeeth, L., Persson, I., Parkinson, J., and Leufkens, H. G., “Evaluating drug toxicity signals: is a hierarchical classification of evidence useful or a hindrance?”, Pharmacoepidemiol Drug Saf, vol. 17, pp. 475-84, 2008.
T. P. van Staa, Cooper, C., Barlow, D., and Leufkens, H. G., “Individualizing the risks and benefits of postmenopausal hormone therapy”, Menopause, vol. 15, pp. 374-81, 2008.
M. J. Willemen, Mantel-Teeuwisse, A. K., Straus, S. M., Leufkens, H. G., and Egberts, A. C., “Psychiatric and cardiovascular comorbidities in patients with diabetes mellitus starting antiobesity drugs”, Obesity (Silver Spring), vol. 16, pp. 2331-5, 2008.
T. P. van Staa, Smeeth, L., Persson, I., Parkinson, J., and Leufkens, H. G., “What is the harm-benefit ratio of Cox-2 inhibitors?”, Int J Epidemiol, vol. 37, pp. 405-13, 2008.
2007
E. M. van de Garde, Souverein, P. C., Hak, E., Deneer, V. H., van den Bosch, J. M., and Leufkens, H. G., “Angiotensin-converting enzyme inhibitor use and protection against pneumonia in patients with diabetes”, J Hypertens, vol. 25, pp. 235-9, 2007.
F. de Vries, Bracke, M., Leufkens, H. G., Lammers, J. W., Cooper, C., and van Staa, T. P., “Fracture risk with intermittent high-dose oral glucocorticoid therapy”, Arthritis Rheum, vol. 56, pp. 208-14, 2007.
T. P. van Staa, Geusens, P., Zhang, B., Leufkens, H. G., Boonen, A., and Cooper, C., “Individual fracture risk and the cost-effectiveness of bisphosphonates in patients using oral glucocorticoids”, Rheumatology (Oxford), vol. 46, pp. 460-6, 2007.
I. Wilting, de Vries, F., Thio, B. M., Cooper, C., Heerdink, E. R., Leufkens, H. G., Nolen, W. A., Egberts, A. C., and van Staa, T. P., “Lithium use and the risk of fractures”, Bone, vol. 40, pp. 1252-8, 2007.
F. de Vries, Souverein, P. C., Cooper, C., Leufkens, H. G., and van Staa, T. P., “Use of beta-blockers and the risk of hip/femur fracture in the United Kingdom and The Netherlands”, Calcif Tissue Int, vol. 80, pp. 69-75, 2007.
2006
T. P. van Staa, Geusens, P., Bijlsma, J. W., Leufkens, H. G., and Cooper, C., “Clinical assessment of the long-term risk of fracture in patients with rheumatoid arthritis”, Arthritis Rheum, vol. 54, pp. 3104-12, 2006.
B. M. Verdel, Souverein, P. C., Egberts, A. C., and Leufkens, H. G., “Difference in risks of allergic reaction to sulfonamide drugs based on chemical structure”, Ann Pharmacother, vol. 40, pp. 1040-6, 2006.
K. B. Handoko, Souverein, P. C., van Staa, T. P., Meyboom, R. H., Leufkens, H. G., Egberts, T. C., and van den Bemt, P. M., “Risk of aplastic anemia in patients using antiepileptic drugs”, Epilepsia, vol. 47, pp. 1232-6, 2006.
E. M. van de Garde, Hak, E., Souverein, P. C., Hoes, A. W., van den Bosch, J. M., and Leufkens, H. G., “Statin treatment and reduced risk of pneumonia in patients with diabetes”, Thorax, vol. 61, pp. 957-61, 2006.
2005
T. P. van Staa, Card, T., Logan, R. F., and Leufkens, H. G., “5-Aminosalicylate use and colorectal cancer risk in inflammatory bowel disease: a large epidemiological study”, Gut, vol. 54, pp. 1573-8, 2005.
F. de Vries, van Staa, T. P., Bracke, M. S., Cooper, C., Leufkens, H. G., and Lammers, J. W., “Severity of obstructive airway disease and risk of osteoporotic fracture”, Eur Respir J, vol. 25, pp. 879-84, 2005.
[Page last reviewed 5 June 2020]