Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
16/10/2023	Trends in General Practice and Emergency Department Use in Children
17/10/2023	The efficacy and safety of concomitant treatment with telmisartan and indapamide in patients with essential arterial hypertension: Outcomes in real world practice
18/10/2023	Autism, epilepsy and central sensitivity syndromes: investigating the co-occurrence of conditions associated with increased brain excitation : inhibition balance
18/10/2023	The associations between antihypertensive medications and microvasucalar, macrovascular diseases and major adverse cardiovascular event (MACE) in people with type 2 diabetes: a population-based cohort study
19/10/2023	Effectiveness and safety of direct oral anticoagulants versus warfarin in patients with atrial fibrillation and mitral stenosis
20/10/2023	Long term cardiovascular safety of febuxostat compared with allopurinol or no urate-lowering treatment in patients with gout: a cohort study in UK primary care using the Clinical Practice Research Datalink.
24/10/2023	Prescription of cardiovascular disease prevention in primary care: a cohort study
30/10/2023	Impact of SSRI and (or) SNRI antidepressant use on cardiovascular health in adult patients with a diagnosis of anxiety disorder: a retrospective cohort study
30/10/2023	Characterising rectal prolapse and rectopexy in the United Kingdom: population characteristics, incidence and surgical procedures
01/11/2023	Using real-world data to replicate a trial on the efficacy and safety of once-weekly semaglutide versus once-daily sitagliptin as an add-on to metformin, thiazolidinediones, or both, in patients with type 2 diabetes (SUSTAIN 2)
01/11/2023	Temporal validation of prognostic models for chronic obstructive pulmonary disease (COPD) and evaluation of methods to correct for calibration drift.
01/11/2023	Epidemiology, outcomes, healthcare resource utilisation, and inequities among amyloidosis patients in the UK, an observational study
01/11/2023	Characterising the clinical features and healthcare resource use associated with thalassaemia in England: a retrospective cohort study
02/11/2023	Evaluating connective tissue diseases and vasculitis services in England using patient outcomes: a model for national audit
02/11/2023	Valvular Heart Disease Diagnosis and Treatment Rates in the UK
02/11/2023	Healthcare inequalities in neurodevelopmental conditions: trends in co-occurring conditions, prescriptions, and outcomes.
02/11/2023	Prescribing of domperidone among postpartum women: feasibility for a study on off-label prescribing.
02/11/2023	Drug utilization study in patients with major depressive disorder - a DARWIN EU study
02/11/2023	Association between leukotriene receptor antagonist use and reduced risk of epileptic seizure: a self-controlled case series study
03/11/2023	Investigating prescription cascades and adverse drug reactions of dementia drug treatments