Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
12/09/2016	Prescription trends among drug pairs with a known drug-drug interaction in primary care
14/09/2016	Trends in the prescription of oral anticoagulants in UK primary care (2009-2015)
22/09/2016	Metformin and the incidence of viral-induced cancers in patients with Type-2 diabetes
30/09/2016	Estimating the annual incidence of paediatric burns across the United Kingdom
04/10/2016	Optimal minimum length of treatment with buprenorphine: A European analysis of medically discontinued opioid dependent patients
11/10/2016	The relationship between prior antibiotic exposure and antibiotic "response failure" in children presenting with acute respiratory tract infections (RTI) in primary care: an observational cohort study
13/10/2016	Oophorectomy and risk of primary liver cancer and fatty liver disease among women in the UK Clinical Practice Research Datalink
13/10/2016	Renal Outcomes with DPP-4 Inhibitors Compared with Sulfonylurea as Add-on to Metformin among Patients with Type 2 Diabetes Mellitus in the UK
13/10/2016	Aclidinium Bromide Post-Authorisation Safety Study to Evaluate the Risk of Cardiovascular Endpoints: Mortality Study
13/10/2016	Rates of cytomegalovirus among children with organ transplants
14/10/2016	What are the long-term health outcomes in low birth weight and premature babies born with chronic lung disease who are discharged home on oxygen?
17/10/2016	Changes in lung function (FEV1) over time in a primary care COPD cohort
18/10/2016	Primary Care and Access To Surgical Treatment For Women With Urinary Incontinence
18/10/2016	Clinical effectiveness of combining two drugs versus monotherapy as initial treatment strategy in hypertension - a matched cohort study in CPRD
18/10/2016	Use of novel regression discontinuity design to investigate safety of statins in the UK Clinical Practice Research Datalink
18/10/2016	Impact of hospital admission upon patterns of primary care prescribing
18/10/2016	Incidence, prevalence, mortality and health-service use among people with systemic sclerosis (scleroderma) in the UK Clinical Practice Research Datalink
24/10/2016	Trends in NHS prescribing of dual NRT (DNRT) and varenicline in pregnancy and effects on infants
24/10/2016	Drug utilization study of dexamfetamine in European countries
28/10/2016	Annual Healthcare Resource Use and Costs for Eczema in Children: A Cost of Illness Study for the English NHS