Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
08/01/2024	Comparing the Risk of Interstitial Lung Disease Between Oral Anticoagulants in Patients with Atrial Fibrillation: A Population-Based Cohort Study
08/01/2024	Developing Algorithms to Predict Individual Patient Response to Anticoagulant, Antidiabetic and Antidepressant Drug Treatment
08/01/2024	Development of prediction models for clinically relevant complications in primary care superficial venous thrombosis patients
08/01/2024	Calculating the impact of optimising preconception health among women with mental illness
09/01/2024	Association between leukotriene receptor antagonist use and the risk of dementia: a population based cohort study
09/01/2024	The epidemiology of sarcoidosis in the United Kingdon
09/01/2024	Incidence of gastro-intestinal, lower respiratory tract, and acute otitis media infections in infants in the United Kingdom between 2012 and 2022.
12/01/2024	Epidemiology of Hypophosphatasia (HPP) in the UK: A Retrospective Cohort Study using Clinical Practice Research Data Link (CPRD)
12/01/2024	Population-level incidence, prevalence and mortality rates in diseases of regulatory interest
12/01/2024	Exploring Healthcare Use Trajectories and the Impact of Duloxetine on Pain-Related Healthcare Use in People with Fibromyalgia: Cohort Study and Emulated Trial in CPRD Aurum.
15/01/2024	What is the rate of occurrence of brief interventions in face to face versus remote consultations for adults in English primary care? An open cohort study of routinely collected healthcare data.
15/01/2024	The association between type 2 diabetes and glucose-lowering therapies and the risk of all-cause mortality and diabetes complications
17/01/2024	Diabetic ketoacidosis (DKA) in adults newly diagnosed with type 1 diabetes (T1D)
18/01/2024	Effectiveness of Human Papillomavirus Vaccines (HPV) to prevent cervical, anal and oropharyngeal cancer: a target trial emulation analysis
19/01/2024	Sodium-glucose co-transporter 2 inhibitors vs dipeptidyl peptidase-4 inhibitors and the risk of ventricular arrhythmia among patients with type 2 diabetes: A population-based cohort study
19/01/2024	Incretin-based drugs and the incidence of endometrial cancer among patients with type 2 diabetes
23/01/2024	Comparing several pancreatic cancer risk scores or models regarding the diagnostic performance and availability of necessary parameters in primary care records of a cohort of patients with recently diagnosed diabetes mellitus
23/01/2024	Modelling kidney disease progression, cardiovascular outcomes and related healthcare costs in chronic kidney disease and assessing the use of risk modifying therapy in chronic kidney disease, diabetes and heart failure
23/01/2024	Preventing steroid harms in people with polymyalgia rheumatica in England primary care - assessing the effect of prophylactic medications on fragility fractures and gastro-intestinal adverse events: a retrospective cohort study
24/01/2024	Exploring the Impact of Frailty Status on the Relationship Between Sodium-Glucose Cotransporter-2 Inhibitors (SGLT2Is) and Adverse Cardiovascular Outcomes in Older People with Type 2 Diabetes