Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
30/04/2018	The impact of type 2 diabetes on survival in patients with cancer independent of its effect on survival in individuals without cancer: a matched cohort analysis
02/05/2018	Impact of removing Quality and Outcomes Framework financial incentives from English Primary Care
02/05/2018	Describing the Cumulative Anticholinergic Burden in Patients Over the Age of 65, With Overactive Bladder, and the Association to Healthcare Resource Utilization. A Retrospective Observational Study Using UK Electronic Medical Records (EMR) data.
02/05/2018	The risk of community-acquired pneumonia in children using proton pump inhibitors or histamine-2 receptor antagonists: a population-based cohort study in the United Kingdom
04/05/2018	Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 10 - Replication of "Prevalence and Burden of Breathlessness in Patients with Chronic Obstructive Pulmonary Disease Managed in Primary Care"
04/05/2018	Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 5 - Replication of "Pioglitazone use and risk of bladder cancer: population based cohort study"
15/05/2018	Causes of death in patients with gout and impact of urate lowering therapy: a population based cohort study
15/05/2018	Developing indicators for failure or delays in recognising clinical deterioration and escalation of care across primary care
15/05/2018	A quasi-experimental study to assess the effectiveness of an educational intervention for improving identification and management of familial hypercholesterolemia in general practice
15/05/2018	The risk of incident osteoarthritis of the hand in women with new use of estrogen replacement therapy or raloxifene: a cohort study with a nested case-control analysis
15/05/2018	Real World Evidence Study to Support Project Obesity: Determine co-diseases scenarios among Overweight and Obese patients. Assessment of metabolic profiles and economic burden of these different scenarios
15/05/2018	Paracetamol versus Ibuprofen and the risk of Myocardial Infarction, Stroke, Gastrointestinal Bleeding and Renal Impairment
15/05/2018	Is seasonal influenza vaccine effectiveness reduced in people receiving repeat vaccinations? A retrospective cohort study using the Clinical Practice Research Database
15/05/2018	Are patients with high normal platelet counts at increased risk of cancer? The NORMA study
15/05/2018	The association between inflammatory markers measured in blood and incident seizures
15/05/2018	The association between bariatric surgery and incident hip or knee arthroplasty: A matched cohort study in obese patients
17/05/2018	An investigation into the effect of quality of antenatal care on the risk of stillbirths in the UK
17/05/2018	High-need patients with chronic conditions: primary and secondary care utilisation and costs, by social and demographic characteristics in high income countries.
21/05/2018	Treatment patterns and burden of agitation in patients with Alzheimer's disease in the UK
21/05/2018	Blood eosinophilia, withdrawal of inhaled corticosteroids and risk of COPD exacerbations and mortality