Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page

Approved studies using CPRD Data

Date of Approval Sort descending Title
29/04/2018 Health care use and cost trajectories of people in the last year of life : improving planning and resource allocation in end of life care
01/05/2018 The risk of community-acquired pneumonia in children using proton pump inhibitors or histamine-2 receptor antagonists: a population-based cohort study in the United Kingdom
01/05/2018 Impact of removing Quality and Outcomes Framework financial incentives from English Primary Care
01/05/2018 Describing the Cumulative Anticholinergic Burden in Patients Over the Age of 65, With Overactive Bladder, and the Association to Healthcare Resource Utilization. A Retrospective Observational Study Using UK Electronic Medical Records (EMR) data.
03/05/2018 Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 10 - Replication of "Prevalence and Burden of Breathlessness in Patients with Chronic Obstructive Pulmonary Disease Managed in Primary Care"
03/05/2018 Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 5 - Replication of "Pioglitazone use and risk of bladder cancer: population based cohort study"
14/05/2018 Paracetamol versus Ibuprofen and the risk of Myocardial Infarction, Stroke, Gastrointestinal Bleeding and Renal Impairment
14/05/2018 Are patients with high normal platelet counts at increased risk of cancer? The NORMA study
14/05/2018 The risk of incident osteoarthritis of the hand in women with new use of estrogen replacement therapy or raloxifene: a cohort study with a nested case-control analysis
14/05/2018 Developing indicators for failure or delays in recognising clinical deterioration and escalation of care across primary care
14/05/2018 Real World Evidence Study to Support Project Obesity: Determine co-diseases scenarios among Overweight and Obese patients. Assessment of metabolic profiles and economic burden of these different scenarios
14/05/2018 Is seasonal influenza vaccine effectiveness reduced in people receiving repeat vaccinations? A retrospective cohort study using the Clinical Practice Research Database
14/05/2018 The association between inflammatory markers measured in blood and incident seizures
14/05/2018 A quasi-experimental study to assess the effectiveness of an educational intervention for improving identification and management of familial hypercholesterolemia in general practice
14/05/2018 Causes of death in patients with gout and impact of urate lowering therapy: a population based cohort study
14/05/2018 The association between bariatric surgery and incident hip or knee arthroplasty: A matched cohort study in obese patients
16/05/2018 High-need patients with chronic conditions: primary and secondary care utilisation and costs, by social and demographic characteristics in high income countries.
16/05/2018 An investigation into the effect of quality of antenatal care on the risk of stillbirths in the UK
20/05/2018 Blood eosinophilia, withdrawal of inhaled corticosteroids and risk of COPD exacerbations and mortality
20/05/2018 Trends in acute exacerbation and related hospitalization among COPD patients in the UK (2005-2013)